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210512 ||| eng |
| 020 |
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|a 9782889194582
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|a 978-2-88919-458-2
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| 100 |
1 |
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|a Tania L. Roth
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| 245 |
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|a Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome
|h Elektronische Ressource
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| 260 |
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|b Frontiers Media SA
|c 2015
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| 300 |
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|a 1 electronic resource (158 p.)
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| 653 |
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|a PTSD
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| 653 |
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|a DNA Methylation
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| 653 |
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|a Medicine / bicssc
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| 653 |
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|a miRNA
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| 653 |
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|a Histones
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| 653 |
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|a stress
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| 653 |
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|a Fear
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| 700 |
1 |
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|a Karestan C. Koenen
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| 700 |
1 |
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|a David M. Diamond
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| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b DOAB
|a Directory of Open Access Books
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| 490 |
0 |
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|a Frontiers Research Topics
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| 500 |
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|a Creative Commons (cc), https://creativecommons.org/licenses/by/4.0/
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| 024 |
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|a 10.3389/978-2-88919-458-2
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| 856 |
4 |
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|u http://journal.frontiersin.org/researchtopic/966/epigenetic-pathways-in-ptsd-how-traumatic-experiences-leave-their-signature-on-the-genome
|7 0
|x Verlag
|3 Volltext
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| 856 |
4 |
2 |
|u https://directory.doabooks.org/handle/20.500.12854/46667
|z DOAB: description of the publication
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| 082 |
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|a 610
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| 520 |
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|a This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry.
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