Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome

This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirica...

Full description

Bibliographic Details
Main Author: Tania L. Roth
Other Authors: Karestan C. Koenen, David M. Diamond
Format: eBook
Language:English
Published: Frontiers Media SA 2015
Series:Frontiers Research Topics
Subjects:
Online Access:
Collection: Directory of Open Access Books - Collection details see MPG.ReNa
LEADER 02200nma a2200373 u 4500
001 EB001978306
003 EBX01000000000000001141208
005 00000000000000.0
007 cr|||||||||||||||||||||
008 210512 ||| eng
020 |a 9782889194582 
020 |a 978-2-88919-458-2 
100 1 |a Tania L. Roth 
245 0 0 |a Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome  |h Elektronische Ressource 
260 |b Frontiers Media SA  |c 2015 
300 |a 1 electronic resource (158 p.) 
653 |a PTSD 
653 |a DNA Methylation 
653 |a Medicine / bicssc 
653 |a miRNA 
653 |a Histones 
653 |a stress 
653 |a Fear 
700 1 |a Karestan C. Koenen 
700 1 |a David M. Diamond 
041 0 7 |a eng  |2 ISO 639-2 
989 |b DOAB  |a Directory of Open Access Books 
490 0 |a Frontiers Research Topics 
500 |a Creative Commons (cc), https://creativecommons.org/licenses/by/4.0/ 
024 8 |a 10.3389/978-2-88919-458-2 
856 4 0 |u http://journal.frontiersin.org/researchtopic/966/epigenetic-pathways-in-ptsd-how-traumatic-experiences-leave-their-signature-on-the-genome  |x Verlag  |3 Volltext 
856 4 2 |u https://directory.doabooks.org/handle/20.500.12854/46667  |z DOAB: description of the publication 
082 0 |a 610 
520 |a This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry.