Development of In-Tether Carbon Chiral Center-Induced Helical Peptide Methodology and Applications
This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “ch...
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| Format: | eBook |
| Language: | English |
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Singapore
Springer Nature Singapore
2021, 2021
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| Edition: | 1st ed. 2021 |
| Series: | Springer Theses, Recognizing Outstanding Ph.D. Research
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| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Introduction
- Method to construct in-tether chiral center constrained helical peptide
- Application in disrupting p53/MDM2 protein-protein interactions
- Fabrication of nanomaterials with in-tether chiral center constrained helical peptide