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Heparanase From Basic Research to Clinical Applications

Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contrib...

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Bibliographic Details
Other Authors: Vlodavsky, Israel (Editor), Sanderson, Ralph D. (Editor), Ilan, Neta (Editor)
Format: eBook
Language:English
Published: Cham Springer International Publishing 2020, 2020
Edition:1st ed. 2020
Series:Advances in Experimental Medicine and Biology
Subjects:
Medicine / Research
Biology / Research
Cancer
Biomedical Research
Cancer Biology
Oncology
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Section 1: Historical Background
  • Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover
  • Chapter 2: gene cloning/overview
  • Chapter 3: gene cloning/melanoma metastasis
  • Chapter 4: gene cloning/cancer/immune system
  • Chapter 5: heparin/HS modifying enzymes
  • Section 2: Crystal Structure/substrate specificity/gene regulation
  • Chapter 6: crystal structure
  • Chapter 7: molecular dynamics, KKDC peptide
  • Chapter 8: Biochemistry/active site
  • Chapter 9: substrate specificity
  • Chapter 10: gene regulation, promoter/Egr1/methylation
  • Chapter 11: SNPs
  • polymorphism
  • Chapter 12: Splice variants
  • Section 3: Cell & tumor biology (general functions & mode of action)
  • Chapter 13: Exosomes/heparan sulfate/heparanse
  • Chapter 14: Exosomes/drug resistance
  • Chapter 15: Nuclear heparanse/transcriptional activity
  • Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy
  • Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG
  • Chapter 33: PG series/biology/Tumor models and clinical trial
  • Chapter34:Chemically modified heparins/Heparin mimetics
  • Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases
  • Chapter 36: IBD/inflammation and cancer/diabetes/obesity
  • Chapter 37: Immune Diabetes
  • Chapter 38 Inflammation, Sepsis/Amyloidosis
  • Chapter 39: Kidney dysfunction
  • Chapter 40: Fibrosis
  • Chapter 41: Viral infection
  • Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy
  • Chapter 43: Eye research
  • Chapter 44: atheroscelerosis, nuclear localization
  • Chapter 45: Yona Nadir (coagulation/tissue factor)
  • Section 7: Heparanse-2 (Hpa2)
  • Chapter 46: Hpa2 gene cloning
  • Chapter 47: UFS
  • urofacial syndrome/peripheral neuropathy
  • Chapter 48: Hpa2: tumor suppressor
  • Chapter 17: Heparan sulfate/stem cells/inflammation
  • Chapter18: Danger signals/HS/platelet heparanse
  • Chapter 19: Heparanse/Intergrins/Melanoma
  • Section 3: Immune Cells/Immnuno-Modulation
  • Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation
  • - Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells
  • Chapter 22: Macrophages, dendritic cells, autoimmunity
  • Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies
  • Chapter 24: NK Cells
  • Section 4: Cancer (heparanse in specific types of cancer)
  • Chapter 25: Myeloma, inhbition, drug resistance
  • Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation
  • Chapter 27: Brain Metastasis/MIR-1258
  • Chapter 28: Gastric cancer/immunization
  • Chapter 29: Head and Neck Cancer
  • Chapter 30: Glioma
  • Chapter 31: Sarcoma
  • Section 5: Inhibitors/clinical trails/cancer

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