Chemoselective Nucleophilic α-Amination of Amides

α-Amino carbonyl compounds are omnipresent in all living organisms, making their selective synthesis highly sought after. However, the synthesis of α-amino amides, a subclass of α-amino carbonyls, in the presence of other carbonyls is usually challenging, due to the required harsh conditions. Miran...

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Bibliographic Details
Main Author: Lemmerer, Miran
Format: eBook
Language:English
Published: Wiesbaden Springer Fachmedien Wiesbaden 2020, 2020
Edition:1st ed. 2020
Series:BestMasters
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Description
Summary:α-Amino carbonyl compounds are omnipresent in all living organisms, making their selective synthesis highly sought after. However, the synthesis of α-amino amides, a subclass of α-amino carbonyls, in the presence of other carbonyls is usually challenging, due to the required harsh conditions. Miran Lemmerer expands a novel chemoselective approach for the synthesis of these intriguing molecules together with Univ.-Prof. Dr. Nuno Maulide’s team. Contents Traditional Umpolung Reactions in Organic Chemistry Insight into Electrophilic Amide Activation Results and Discussion of a New α-Amination Method via Umpolung of Amides α-Arylation of Carbonlys via a Smiles Rearrangement Target Groups Scientists and students in the field of organic chemistry, especially in methodology development The Author Miran Lemmerer is currently pursuing his PhD studies under supervision of Prof. Dr. Nuno Maulide at the Department of Organic Chemistry, University of Vienna, Austria.
Physical Description:XII, 60 p. 1 illus online resource
ISBN:9783658300203