Regulation of Cancer Immune Checkpoints Molecular and Cellular Mechanisms and Therapy
This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clini...
| Other Authors: | |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Singapore
Springer Nature Singapore
2020, 2020
|
| Edition: | 1st ed. 2020 |
| Series: | Advances in Experimental Medicine and Biology
|
| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Introduction
- Molecular and cellular functions of CTLA-4 pathway
- Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond
- Discovery of new immune checkpoints: family grows up
- Mechanisms of resistance to checkpoint blockade therapy
- Molecular events behind adverse effects
- Rational discovery of response biomarkers
- Spatiotemporal changes in checkpoint molecule expression
- Functions of checkpoint molecules beyond immune evasion
- Genetic alterations and checkpoint expression
- Regulations on messenger RNA: wires and nodes
- Folded or degraded in endoplasmic reticulum
- Mono- and poly-ubiquitination: tags for fates
- Lysosome as the black hole for checkpoint molecules
- Phosphorylation: a fast switch for checkpoint signalling
- Palmitoylation as a signal for delivery
- Checkpoints under traffic control: from and to organelles
- Exosome and secretion: action on?
- Macromolecules and antibody-based drugs
- Mechanisms inspired targeting peptides
- Small molecular inhibitors
- Therapeutic development of immune checkpoint blockers
- Concluding remarks