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Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders

This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological...

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Bibliographic Details
Main Author: Ganai, Shabir Ahmad
Format: eBook
Language:English
Published: Singapore Springer Nature Singapore 2019, 2019
Edition:1st ed. 2019
Subjects:
Neuroscience
Post-translational Modifications
Neurosciences
Protein Biochemistry
Genetics And Genomics
Genetics
Post-translational Modification
Pharmacology
Proteins 
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Chapter 1. Role of Epigenetics in neurological diseases
  • Chapter 2. Epigenetic enzymes and the drawbacks of conventional therapeutic regimens
  • Chapter 3. Distinct classes of HDACs
  • Chapter 4. HDAC implications in neurological diseases
  • Chapter 5. HDAC inhibitors and their structurally distinct groups
  • Chapter 6. HDAC inhibitors as novel therapeutic option against therapeutically challenging neurological disorders
  • Chapter 7. Current Challenges with HDAC inhibitor based therapeutic intervention against neurological maladies
  • Chapter 8. Escalating need of isoform selective inhibitors for enhanced therapeutic efficacy
  • Chapter 9. Combinatorial therapeutic regimens using HDAC inhibitors in conjunction with conventional therapeutic agents
  • Chapter 10. Future directions of epigenetic research in tackling neurological complications

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