Clinical review report: Ertugliflozin (Steglatro) (Merck Canada Inc.) : indication : type 2 diabetes mellitus

Diabetes mellitus is a metabolic disease that is characterized by persistent elevations in blood glucose (hyperglycemia). This persistent elevated blood glucose causes damage to blood vessels on a microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular (peripheral artery disease,...

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Corporate Author: Canadian Agency for Drugs and Technologies in Health
Format: eBook
Language:English
Published: Ottawa (ON) CADTH February 2019, 2019
Edition:Final (with redactions)
Series:CADTH common drug review
Subjects:
Online Access:
Collection: National Center for Biotechnology Information - Collection details see MPG.ReNa
Summary:Diabetes mellitus is a metabolic disease that is characterized by persistent elevations in blood glucose (hyperglycemia). This persistent elevated blood glucose causes damage to blood vessels on a microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular (peripheral artery disease, cardiovascular [CV] disease) level. Diabetes is one of the most common chronic diseases in Canada. Diabetes Canada estimated that there were 3.4 million people (9.3% of the population) with diabetes in 2015, and by 2025 this number will have increased to five million people (12.1%). The objective was to perform a systematic review of the beneficial and harmful effects of ertugliflozin (ERT) 5 mg and 15 mg tablets to improve glycemic control in adult patients with type 2 diabetes mellitus for whom metformin is inappropriate due to contraindications or intolerance (as monotherapy); or in combination with metformin, or metformin and sitagliptin, when these therapies, along with diet and exercise, do not provide adequate glycemic control. This review was conducted in tandem with an evaluation of the ERT/metformin fixed-dose combination product, Segluromet
Physical Description:1 PDF file (111 pages) illustrations