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190824 r ||| eng |
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|a Pharmacoeconomic review report: Ticagrelor (Brilinta)
|h Elektronische Ressource
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|a CDR pharmacoeconomic review report for Brilinta
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|a Ticagrelor (Brilinta)
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|a Ottawa (ON)
|b CADTH
|c 2016, August 2016
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300 |
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|a 1 PDF file (vi, 15 pages)
|b illustrations
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|a Includes bibliographical references
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653 |
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|a Atherosclerosis / prevention & control
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653 |
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|a Ticagrelor / therapeutic use
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653 |
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|a Atherosclerosis / economics
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653 |
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|a Thrombosis / economics
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653 |
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|a Thrombosis / prevention & control
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653 |
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|a Cost-Benefit Analysis
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653 |
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|a Myocardial Infarction / prevention & control
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653 |
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|a Ticagrelor / economics
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653 |
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|a Atherosclerosis / drug therapy
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653 |
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|a Thrombosis / drug therapy
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|a Canadian Agency for Drugs and Technologies in Health
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|a eng
|2 ISO 639-2
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|b NCBI
|a National Center for Biotechnology Information
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|a CADTH common drug review
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|u https://www.ncbi.nlm.nih.gov/books/NBK538959
|3 Volltext
|n NLM Bookshelf Books
|3 Volltext
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|a 330
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|a Ticagrelor is an oral, direct-acting, selective and reversibly binding P2Y12 receptor antagonist that prevents adenosine diphosphate (ADP)-mediated P2Y12-dependent platelet activation and aggregation. The proposed new indication is ticagrelor, combined with low-dose (75 mg to 150 mg) acetylsalicylic acid (ASA), for the secondary prevention of atherothrombotic events in adult patients with a history of myocardial infarction (MI) (occurred at least one year ago) and a high risk of developing an atherothrombotic event. The suggested dose is 60 mg twice daily, orally. Ticagrelor should be combined with ASA unless ASA is contraindicated. Treatment with ticagrelor should be continued in patients with a history of MI for as long as the patient remains at high risk of an atherothrombotic event for a duration up to three years. At a submitted price of $1.48 per 60 mg tablet, the daily cost of treatment is $2.96 per patient (or $1,080 annually). The manufacturer submitted a cost-utility analysis to assess the cost-effectiveness of ticagrelor + ASA versus ASA alone in patients with a history of MI (MI occurred at least one year ago) and a high risk of developing an atherothrombotic event. The analysis was based on an individual patient simulation model estimating long-term health care costs and quality-adjusted life-years (QALYs) over a lifetime horizon (40 years), from the perspective of the Canadian public health care payer. The manufacturer reported that ticagrelor + ASA was associated with greater QALYs and higher costs than ASA alone, with an estimated incremental cost per QALY gained of $59,724
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