| Summary: | RAND researchers conducted a systematic review that synthesized evidence from randomized controlled trials of acupuncture -- used adjunctively or as monotherapy -- to assess its efficacy and safety in treating adults with major depressive disorder. Outcomes of interest included depressive symptoms, response to treatment, remission, relapse, health-related quality of life, and adverse events. Study details were documented in detailed evidence tables and summarized in a narrative synthesis. The quality of evidence was assessed using the Grades of Recommendation, Assessment, Development, and Evaluation (or GRADE) approach
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