Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents
This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considera...
| Main Authors: | , , , |
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| Format: | eBook |
| Language: | English |
| Published: |
Tokyo
Springer Japan
2018, 2018
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| Edition: | 1st ed. 2018 |
| Series: | JSS Research Series in Statistics
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- 1. Introduction
- 2. Phase I Trials for Drug Development in Oncology
- 3. A Summary of Dose
- Finding Methods in Standard Phase I Trials
- 4. Phase I Trials for Combination of Two Agents
- 5. Phase I Trials for Joint Assessment of Both Efficacy and Toxicity
- 6. Additional Topics on Adaptive Dose
- Finding Methods