Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considera...

Full description

Bibliographic Details
Main Authors: Hirakawa, Akihiro, Sato, Hiroyuki (Author), Daimon, Takashi (Author), Matsui, Shigeyuki (Author)
Format: eBook
Published: Tokyo Springer Japan 2018, 2018
Edition:1st ed. 2018
Series:JSS Research Series in Statistics
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • 1. Introduction
  • 2. Phase I Trials for Drug Development in Oncology
  • 3. A Summary of Dose
  • Finding Methods in Standard Phase I Trials
  • 4. Phase I Trials for Combination of Two Agents
  • 5. Phase I Trials for Joint Assessment of Both Efficacy and Toxicity
  • 6. Additional Topics on Adaptive Dose
  • Finding Methods