Proteases in Human Diseases

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems i...

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Bibliographic Details
Other Authors: Chakraborti, Sajal (Editor), Chakraborti, Tapati (Editor), Dhalla, Naranjan S. (Editor)
Format: eBook
Language:English
Published: Singapore Springer Nature Singapore 2017, 2017
Edition:1st ed. 2017
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • 1. Matrix metalloproteases in breast carcinoma, immunohistology and prognosis
  • 2. Matrix metalloproteases in parasite infection
  • 3. Cysteine cathepsins: In health and rheumatoid arthritis
  • 4. Protective role of antiproteases in radiation induced damage
  • 5. Role of proteases in the regulation of N-myristoyltransferase
  • 6. Proteases in cancer: Potential therapeutic targets
  • 7. MMPs in oral squamous cell carcinoma
  • 8. Caspase regulatory mechanisms: Implications in pathogenesis and therapeutics
  • 9. Physiological and pathological functions of mitochondrial proteases
  • 10. Proteases of parasitic helminths: their metabolic role in establishment of infection in the host
  • 11. Cysteine proteases of parasitic helminths
  • 12. targeting proteases in urine for bladder cancer diagnosis
  • 13. Intramembrane cleaving proteases (ICLiPs), particularly the gamma secretase protease and its role in neurodegeneration, cancer and innate immune signalling
  • 14. Contribution of matrix metalloproteases in cardiovascular diseases
  • 15. OPG/RANKL-protease axis in cardiometabolic diseases
  • 16. Proteases and protease inhibitors in male reproduction
  • 17. The role of MMP-2 and -9 in embryonic neural crest cells and their derivatives
  • 18. Proteolytic ubiquitin like proteins
  • 19. C.albicans aspartic proteases: role of these enzymes in degradation of crucial human host proteins at the place of infection and a possible implications of the protease action for propagation of infection.
  • 20. MMPs in cancer
  • 21. Pathophysiological roles played by proteases of Psedomonas aeruginosa: crucial multifunctional molecules involved in the host infection
  • 22. Role of proteases on activating cell death pathways
  • 23. varying faces of matrix metalloproteinases in cardiovascular diseases
  • 24. kallikreins and kallikrein related peptides (KLKs) in health and disease
  • 25. Endogenous proteases in tumoral progression