Group-Sequential Clinical Trials with Multiple Co-Objectives
This book focuses on group sequential methods for clinical trials with co-primary endpoints based on the decision-making frameworks for: (1) rejecting the null hypothesis (stopping for efficacy), (2) rejecting the alternative hypothesis (stopping for futility), and (3) rejecting the null or alternat...
| Main Authors: | , , , |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Tokyo
Springer Japan
2016, 2016
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| Edition: | 1st ed. 2016 |
| Series: | JSS Research Series in Statistics
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- 1. Introduction
- 2. Early Stopping for Efficacy in Clinical Trials with multiple co-primary endpoints
- 3. Sample size recalculation based on observed effects at interim
- 4. Early stopping for futility in Clinical Trials with multiple co-primary endpoints
- 5. Early stopping for futility or Efficacy in Clinical Trials with multiple co-primary endpoints
- 6. Clinical Trials with multiple primary endpoints
- 7. Group-sequential designs for three-arm noninferiority clinical trials
- 8. Further development: topics not covered in this book