Table of Contents:
  • Twin, family, and adoption studies
  • Central mechanisms involved in eating behavior
  • Genetic variation relevant for body weight regulation
  • Molecular synopsis
  • Parabiosis experiments
  • Cloning of the obese gene
  • Obesity syndromes
  • Monogenic forms of obesity
  • Leptin deficiency
  • Leptin signaling: adaptation to semi-starvation
  • Leptin and hypothalamic amenorrhea
  • Semi starvation induced hyperactivity "anorexia based hyperactivity"
  • POMC mutations in humans