Molecular Structures and Structural Dynamics of Prion Proteins and Prions Mechanism Underlying the Resistance to Prion Diseases
This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) t...
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| Format: | eBook |
| Language: | English |
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Dordrecht
Springer Netherlands
2015, 2015
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| Edition: | 1st ed. 2015 |
| Series: | Focus on Structural Biology
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Basic Knowledge
- The Homology Structure and Dynamics
- The NMR Structure and Dynamics of the Wild-type and Mutants
- Compared with the NMR Structure and Dynamics of Humans and Mice
- Compared with the NMR Structure and Dynamics of Dogs and Horses
- Compared with a Homology Structure and Dynamics of Buffaloes
- Compared with NMR Structure and Dynamics of Elks
- Compared with the X-ray Structure and Dynamics of Rabbits
- Surface Electrostatic Charge Distributions
- The Hydrophobic Region PrP(109–136)
- The Hybrid Method of Steepest Descent - Conjugate Gradient with Simulated Annealing
- Hybrid Method of Discrete Gradient with Simulated Annealing or Genetic Algorithm
- A Novel Canonical Dual Global Optimization Computational Approach
- The Hybrid Method of Evolutionary Computations with Simulated Annealing
- Simulated Annealing Refined Replica Exchange Global Search Algorithm
- LBFGS Quasi-Newtonian Methods for MM Prion AGAAAAGA Amyloid Fibrils
- Particle Swarm Global Optimization Search Algorithm
- A Summary of the Research Works on AGAAAAGA.