Proteostasis and Chaperone Surveillance

Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The c...

Full description

Bibliographic Details
Other Authors: Singh, Laishram Rajendrakumar (Editor), Dar, Tanveer Ali (Editor), Ahmad, Parvaiz (Editor)
Format: eBook
Language:English
Published: New Delhi Springer India 2015, 2015
Edition:1st ed. 2015
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
LEADER 02898nmm a2200301 u 4500
001 EB001085376
003 EBX01000000000000000844740
005 00000000000000.0
007 cr|||||||||||||||||||||
008 151215 ||| eng
020 |a 9788132224679 
100 1 |a Singh, Laishram Rajendrakumar  |e [editor] 
245 0 0 |a Proteostasis and Chaperone Surveillance  |h Elektronische Ressource  |c edited by Laishram Rajendrakumar Singh, Tanveer Ali Dar, Parvaiz Ahmad 
250 |a 1st ed. 2015 
260 |a New Delhi  |b Springer India  |c 2015, 2015 
300 |a XII, 180 p. 26 illus  |b online resource 
505 0 |a Part 1: Maintaining Proteostasis -- 1. Structural Allostery and Protein-Protein Interactions of Sin3 -- 2. Protein Posttranslational Modifications: Role in Protein Structure, Function and Stability -- 3. Protein Folding and Aggregation: A revisit of basic conception -- Part 2: Proteopathy: Failure of proteostasis -- 4. Protein Folding: From Normal Cellular Function to Pathophysiology -- 5. Protein Misfolding Diseases: In perspective of Gain and loss-of-function -- 6. Amyloid formation in Alzheimer’s disease -- 7. Advances in modulation of Proteopathies, the devil spread from head to toe -- Part 3: Chaperone surveillance of proteopathy -- 8. Small Molecule Osmolytes can Modulate Proteostasis -- 9. Pharmacological Chaperones in Protein Aggregation Disorders 
653 |a Proteins 
653 |a Protein Biochemistry 
653 |a Proteins  
700 1 |a Dar, Tanveer Ali  |e [editor] 
700 1 |a Ahmad, Parvaiz  |e [editor] 
041 0 7 |a eng  |2 ISO 639-2 
989 |b Springer  |a Springer eBooks 2005- 
028 5 0 |a 10.1007/978-81-322-2467-9 
856 4 0 |u https://doi.org/10.1007/978-81-322-2467-9?nosfx=y  |x Verlag  |3 Volltext 
082 0 |a 572.6 
520 |a Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, the consequences of proteostatic system failure, and how chaperone systems constantly maintain proteostasis. In addition, the book presents in detail different treatment strategies for diseases caused by proteostatic system failure, as well as the inhibition of proteostatic failure using small molecule compounds. It examines advances in the modulation of proteopathies, providing a comprehensive source of key mechanistic insights on these diseases. As such, the book offers a valuable resource for beginners and more experienced investigators alike who are looking for detailed and reliable information on protein homeostasis, the diseases that can develop due to related imbalances, and the essential role of molecular and chemical chaperones