Bevacizumab the first FDA-approved angiogenesis inhibitor in the treatment of non-small cell lung cancer

Bibliographic Details
Main Author: Evans, Tracey L.
Format: eBook
Language:English
Published: London Henry Stewart Talks 2009, 2009
Series:Cancer therapy : latest thinking in efficacy and toxicity
Subjects:
Online Access:
Collection: Henry Stewart Talks - Collection details see MPG.ReNa
Table of Contents:
  • Lung cancer incidence
  • Survival by treatment group
  • Selected trials of novel agents + chemotherapy
  • Bevacizumab
  • Vascular Endothelial Growth Factor (VEGF)
  • Principles of angiogenesis
  • Bevacizumab in NSCLC: not for everybody
  • Randomized phase II trial of Paclitaxel/Carboplatin with/without Bevacizumab in NSCLC
  • Hemorrhagic events
  • Example of tumor cavitation in lung following treatment with chemotherapy and Bevacizumab
  • Patient haracteristics
  • Response rates
  • Hematologic and non-hematologic toxicity
  • Treatment related deaths
  • Efficacy by gender and age
  • NCCN pactice guidelines in oncology-v.2.2008
  • AVAiL: phase III trial of Bevacizumab + Gemcitabine and Cisplatin in advanced non|squamous cell NSCLC
  • Second line therapy for advanced NSCLC: the role of Bevacizumab
  • Adjuvant therapy in NSCLC
  • Can a broader range of patients be safely treated with Bevacizumab?
  • Protocol AVF3744g: BRIDGE trial