Molecular identification of the CRAC channel
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| Format: | eBook |
| Language: | English |
| Published: |
London
Henry Stewart Talks
2007, 2007
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| Series: | Calcium signaling I : regulation, mechanisms, effectors, role in disease and recent advances
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| Subjects: | |
| Online Access: | |
| Collection: | Henry Stewart Talks - Collection details see MPG.ReNa |
Table of Contents:
- Background on Calcium signaling and ion channels in the immune system, role of CRAC channels in lymphocyte activation
- Discovery of Stim and STIM1 by RNA interference screen in Drosophila S2 cells
- Stim as an ER Calcium sensor and as a messenger to the plasma membrane
- Genome-wide RNA interference screen and the discovery of Orai
- Amplifying CRAC current by co-expression of Stim and Orai
- Molecular identification of CRAC channels by altered ion selectivity in a mutant of Orai
- How does the CRAC channel activate?