Cancer systems biology dissection and analysis of context-specific molecular interaction networks
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
London
Henry Stewart Talks
2009, 2009
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| Series: | Microarrays : their design and use
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| Subjects: | |
| Online Access: | |
| Collection: | Henry Stewart Talks - Collection details see MPG.ReNa |
Table of Contents:
- The evolution of systems biology
- Dissecting molecular interaction networks
- Algorithm for the Reverse-Engineering of Accurate Cellular Networks (ARACNe)
- Computing the mutual information
- Application to the MYC proto-oncogene
- Can ARACNe be applied to signaling networks
- Experimental data
- Dataset composition
- Discrete data handling
- EGFR network
- Modulator Inference by Network Dynamics (MINDy)
- Multivariate dependency model
- Conditional interactions
- STK38
- Top MYC modulators
- Signalome transfactome network
- Biochemical validation
- Bayesian evidence integration algorithm (BEIA)
- Interactome validation
- Interactome-Dysregulation Enrichment Analysis (IDEA)
- The "barcode" of cancer
- Master regulator analysis (MRA)
- The germinal center
- Shadowing and synergy