WNK1 pathway and its role in regulating hypertension

Bibliographic Details
Main Author: Alessi, Dario
Format: eBook
Language:English
Published: London Henry Stewart Talks 2011, 2011
Series:Protein phosphorylation
Subjects:
Online Access:
Collection: Henry Stewart Talks - Collection details see MPG.ReNa
Table of Contents:
  • Mutations in WNK kinases cause familial hypertension
  • WNK1 interacts with and activates SPAK and OSR1
  • Physiological functions of SPAK and OSR1
  • Hyperosmotic conditions affect NKCC1 via WNK1 and SPAK/OSR1
  • A suggested mechanism of action for Thiazide diuretics in Gordon's syndrome patients
  • How the WNK pathway regulates blood pressure-a current model
  • Defining physiological roles of SPAK in knock-in mice
  • MO25 also regulates the activity of SPAK/OSR1
  • Functions and schematic representation of LKB1 and SPAK/OSR1 protein complexes