Table of Contents:
  • HIV life cycle
  • The HIV-1 genome
  • Synthesis of HIV-1 envelope glycoproteins
  • Targets for antiretroviral therapy
  • Mechanism of HIV-1 entry
  • HIV entry inhibition
  • HIV-1 binding inhibitors
  • HIV-1 coreceptor inhibitors
  • Viral composition of pure/mixed populations
  • CXCR4 antagonists
  • Drugs blocking gp120-CCR5 interaction
  • Maraviroc
  • MOTIVATE 1 and 2 clinical trials
  • Coreceptor tropism by treatment status
  • Resistance in the absence of coreceptors
  • HIV-1 fusion inhibitors
  • TORO trials
  • Predictors of virological response
  • The virus-inhibitory peptide (virip)
  • New strategies to prevent HIV infection