Table of Contents:
  • Difficult asthma and severe refractory asthma
  • Heterogeneous reasons for severe asthma
  • "High dose" therapy
  • Treatments for severe asthma
  • Eosinophilic vs. non eosinophilic inflammation
  • Effect of CRS treatment on asthma
  • Mechanism of action of anti IgE
  • Effect of anti IgE on severe asthma exacerbations
  • Effect of anti IL-5 (mepolizumab) on spontaneous asthma exacerbations
  • Clarithromycin in neutrophilic asthma
  • Macrolides in chronic stable asthma
  • Mechanisms of asthma severity in obese patients
  • Implications for the future