|
|
|
|
| LEADER |
02876nmm a2200385 u 4500 |
| 001 |
EB001081789 |
| 003 |
EBX01000000000000000841196 |
| 005 |
00000000000000.0 |
| 007 |
cr||||||||||||||||||||| |
| 008 |
151019 ||| eng |
| 100 |
1 |
|
|a Saunders, Norman
|
| 245 |
0 |
0 |
|a Barrier mechanisms in the developing brain
|h Elektronische Ressource
|b protection or vulnerability?
|c Norman Saunders
|
| 260 |
|
|
|a London
|b Henry Stewart Talks
|c 2014, 2014
|
| 300 |
|
|
|a 1 online resource (1 streaming video file (57 min.)
|b color, sound)
|
| 505 |
0 |
|
|a The brain develops within a well-defined internal environment -- The properties of this internal environment are determined by transporters in the cellular interfaces between the blood, brain and cerebrospinal fluid -- The transporters are effective because the intercellular spaces between the cells in the interfaces are sealed by tight junctions -- The transporters are both influx and efflux and many are active very early in brain development -- Although brain barrier mechanisms are present very early in development they are vulnerable to pathological conditions e.g. inflammation, which may result in barrier dysfunction and damage to the fragile developing brain -- These mechanisms thus provide protection and a stable internal environment, but some may render the developing brain more vulnerable e. g. inward transport of toxins such as mercury via a normal amino acid transporter
|
| 653 |
|
|
|a Brain / embryology
|
| 653 |
|
|
|a Blood-brain barrier
|
| 653 |
|
|
|a Capillary Permeability
|
| 653 |
|
|
|a Biological transport
|
| 653 |
|
|
|a Brain / growth & development
|
| 653 |
|
|
|a Blood-Brain Barrier / growth & development
|
| 653 |
|
|
|a Maternal Exposure
|
| 653 |
|
|
|a Blood-Brain Barrier / cytology
|
| 653 |
|
|
|a Carrier Proteins
|
| 653 |
|
|
|a Intercellular Junctions / metabolism
|
| 653 |
|
|
|a Blood-Brain Barrier / embryology
|
| 653 |
|
|
|a Brain / Growth
|
| 653 |
|
|
|a Blood-Brain Barrier / metabolism
|
| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
|
| 989 |
|
|
|b HST
|a Henry Stewart Talks
|
| 490 |
0 |
|
|a The blood-brain barrier : understanding the regulatory gatekeeper between brain and body
|
| 500 |
|
|
|a Animated audio-visual presentation with synchronized narration. - Title from title frames. - Mode of access: World Wide Web. - System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
|
| 856 |
4 |
2 |
|u https://hstalks.com/bs/p/277
|3 Series
|
| 856 |
4 |
0 |
|u https://hstalks.com/bs/2721
|x Verlag
|z Streaming video file
|
| 082 |
0 |
|
|a 570
|