Table of Contents:
  • Cohesin regulates gene expression and development in Drosophila and Humans
  • Cohesin binds a subset of active genes at transcription start sites
  • Cohesin directly regulates many genes Important for growth and development
  • Cohesin cooperates with polycomb epigenetic silencing complexes to restrain gene expression
  • Cohesin selectively binds genes with paused RNA Polymerase and regulates transition to transcriptional elongation
  • Questions regarding the roles of cohesin in gene regulation and development and relevance to human disease