The epidermis and blistering disorders pemphigus
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
London
Henry Stewart Talks
2014, 2014
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| Series: | Skin biology
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| Subjects: | |
| Online Access: | |
| Collection: | Henry Stewart Talks - Collection details see MPG.ReNa |
Table of Contents:
- Pemphigus vulgaris (PV)
- PV is a life-long, life-threatening, IgG autoantibody-mediated blistering disease affecting oral/esophageal surfaces and/or skin. The fundamental myths hampered progress of pemphigus research toward development of a safe and efficient treatment. Elucidation of intimate mechanisms of keratinocyte detachment and death in pemphigus has challenged the monopathogenic explanation of disease focused of desmoglein autoimmunity. This chapter discusses recent advances of knowledge on PV, scrutinize old dogmas, resolve controversies and opens novel perspectives for treatment. PV is caused by a variety of autoantibodies that synergize with effectors of apoptotic and oncotic pathways, serine proteases, and inflammatory cytokines to overcome the natural resistance and activate the cell death program in keratinocytes. The concept of apoptolysis distinguishes the unique mechanism of autoantibody-induced keratinocyte damage in PV from other known forms of cell de