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150908 ||| eng |
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|a 9783319183145
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| 100 |
1 |
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|a Zatz, Mayana
|e [editor]
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| 245 |
0 |
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|a Stem Cells in Modeling Human Genetic Diseases
|h Elektronische Ressource
|c edited by Mayana Zatz, Oswaldo Keith Okamoto
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| 250 |
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|a 1st ed. 2015
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| 260 |
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|a Cham
|b Springer International Publishing
|c 2015, 2015
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| 300 |
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|a XII, 147 p. 16 illus., 15 illus. in color
|b online resource
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| 505 |
0 |
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|a Modeling Fragile X Syndrome in Human Pluripotent Cells -- Induced Pluripotent Stem Cells in Familial Dilated Cardiomyopathy.- Induced Pluripotent Stem Cells and Amyotrophic Lateral Sclerosis -- IPS Cells and Spinocerebellar Ataxia -- Induced Pluripotent Stem Cells and Vascular Disease -- iPS Cells and Cardiomyopathies -- Cancer Stem Cells and Chemoresistance -- Stem Cells in Autism Spectrum Disorders
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| 653 |
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|a Medical Genetics
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| 653 |
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|a Regenerative Medicine and Tissue Engineering
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| 653 |
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|a Stem cells
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| 653 |
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|a Medical genetics
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| 653 |
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|a Stem Cell Biology
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| 653 |
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|a Regenerative medicine
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| 700 |
1 |
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|a Keith Okamoto, Oswaldo
|e [editor]
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| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b Springer
|a Springer eBooks 2005-
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| 490 |
0 |
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|a Stem Cell Biology and Regenerative Medicine
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| 028 |
5 |
0 |
|a 10.1007/978-3-319-18314-5
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| 856 |
4 |
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|u https://doi.org/10.1007/978-3-319-18314-5?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
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|a 571.6
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| 082 |
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|a 61,602,774
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| 520 |
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|a Using stem cells to investigate currently untreatable human genetic diseases is the focus of this book. Several applications of the Nobel-Prize winning, revolutionary iPS cell technology are explored in detail, including in schizophrenia, autism, Huntington’s disease, Alzheimer’s disease, spinocerebellar ataxia, medulloblastoma heterogeneity, progeria, age-related macular degeneration, and muscular dystrophy . The book is divided into seven sections, each composed of authoritative and detailed chapters. The first section provides a theoretical and practical overview of stem cells in disease modeling. The following sections divide stem cell applications into various classes of pathology- psychiatric disorders, neurodegenerative disease, neurogenesis-associated disorders, and laminopathies. Following these sections, the book discusses the future perspectives- and challenges- of iPS technology. Broad in scope and in audience, Stem Cells in Modeling Human Genetic Diseases for postgraduate students, scientists, and clinicians interested in applications of the rapidly developing field of stem cell research in disease modeling and drug development and its dynamic role within regenerative medicine
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