Assessing Rare Variation in Complex Traits Design and Analysis of Genetic Studies
This unique volume is the first to cover a wide range of design and analysis issues in genetic studies of rare variants, with contributions from experts in the field, through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES. The book presents state-of-the-art met...
| Other Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
New York, NY
Springer New York
2015, 2015
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| Edition: | 1st ed. 2015 |
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| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Calling Rare Variants from Genotype Data
- Calling Variants from Sequence Data
- Rare Variant Quality Control
- Rare Structural Variants
- Functional Annotation of Rare Genetic Variants
- The 1000 Genomes Project
- The UK10K Project
- Population Isolates
- Natural Selection at Rare Variants
- Collapsing Approaches for the Association Analysis of Rare Variants
- Rare Variant Association Analysis: Beyond Collapsing Approaches
- Significance Thresholds for Rare Variant Signals
- Power of Rare Variant Aggregate Tests
- Replicating Sequence-based Association Studies of Rare Variants
- Meta-analysis of Rare Variants
- Population Stratification of Rare Variants
- Use of Appropriate Controls in Rare Variant Studies
- Trans-ethnic Fine-mapping of Rare Causal Variants