Life Extension Lessons from Drosophila
This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in biogerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie agin...
| Other Authors: | , , |
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| Format: | eBook |
| Language: | English |
| Published: |
Cham
Springer International Publishing
2015, 2015
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| Edition: | 1st ed. 2015 |
| Series: | Healthy Ageing and Longevity
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Preface
- SECTION I: Genetic regulation of longevity
- Mutations and quantitative genetic variation: lessons from Drosophila
- Modulation of Drosophila lifespan by neuronal genes
- Life span, stress resistance and age-dependent transcriptome dynamics in fruit flies with constitutive and conditional overexpression of GADD45
- Superoxide dismutase over-expression and the mitochondrial unfolded protein response
- Effect of Wolbachia infection on aging and longevity-associated genes in Drosophila
- SECTION II: Drosophila models for aging-associated diseases
- Skeletal muscle homeostasis and aging
- Drosophila models of cardiac disease
- Genetic modulation of cardiac functional aging
- Functional links between circadian clocks, redox state and aging in Drosophila
- Drosophila models in therapeutic drug discovery
- SECTION III: Life-extending treatments
- Phytochemicals with lifespan extension effect in Drosophila
- Life extension in Drosophila by inhibitors of histone deacetylases
- Drosophila healthspan extension using dietary manipulation
- The effect of the artificial atmosphere on the flies’ longevity
- Effects of several mild stresses applied in adults on aging and longevity
- Life extension via stage-specific drug interventions in Drosophila
- Index