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12145nmm a2200601 u 4500 |
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EBX01000000000000000826247 |
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150528 ||| eng |
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|a 0123944465
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|a 1299619185
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|a 9780123944467
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|a 0123947952
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|a 9780123947956
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|a 9781299619180
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| 100 |
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|a Issaq, Haleem J.
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| 245 |
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|a Proteomic and metabolomic approaches to biomarker discovery
|h [electronic resource]
|h Elektronische Ressource
|c edited by Haleem J. Issaq, Timothy D. Veenstra
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| 260 |
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|a Amsterdam
|b Elsevier/AP
|c 2013, ©2013
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| 300 |
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|a online resource (xv, 472 pages)
|b illustrations
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| 505 |
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|a Includes bibliographical references and index
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|a Protein Identification / Timothy D. Veenstra / Haleem J. Issaq / Stephen D. Fox / Que N. Van -- Metabolite Identification in Global Metabolomics / Timothy D. Veenstra / Haleem J. Issaq / Stephen D. Fox / Que N. Van -- References / Timothy D. Veenstra / Haleem J. Issaq / Stephen D. Fox / Que N. Van -- Introduction / Xudong Yao / Mary Joan Castillo / Adam J. McShane --
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| 505 |
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|a Quality Control, Data Analysis, and Biomarker Detection / Georgios A. Theodoridis / Ian D. Wilson / Robert Plumb / Helen G. Gika -- Metabolite Identification and Biomarker Validation / Georgios A. Theodoridis / Ian D. Wilson / Robert Plumb / Helen G. Gika -- Conclusions / Georgios A. Theodoridis / Ian D. Wilson / Robert Plumb / Helen G. Gika -- References / Georgios A. Theodoridis / Ian D. Wilson / Robert Plumb / Helen G. Gika -- Analysis of Metabolite Profiles Using Capillary Electrophoresis-Mass Spectrometry / Cheng S. Lee / Chenchen Wang -- Analysis of Protein Expression Levels Using Capillary Electrophoresis-Mass Spectrometry / Cheng S. Lee / Chenchen Wang -- Conclusion / Cheng S. Lee / Chenchen Wang -- Acknowledgments / Cheng S. Lee / Chenchen Wang -- References / Cheng S. Lee / Chenchen Wang -- Introduction / Egisto Boschetti / Pier Giorgio Righetti / Giovanni Candiano --
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| 505 |
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|a Protein Biomarker Discovery and Development Pipeline / Eleftherios P. Diamandis / Ihor Batruch / Maria P. Pavlou / Andrei P. Drabovich -- Proteomic Samples / Andrei P. Drabovich / Maria P. Pavlou / Ihor Batruch / Eleftherios P. Diamandis -- Protein Identification by Mass Spectrometry / Andrei P. Drabovich / Maria P. Pavlou / Ihor Batruch / Eleftherios P. Diamandis -- Post-Translational Modifications as Disease Biomarkers / Andrei P. Drabovich / Eleftherios P. Diamandis / Ihor Batruch / Maria P. Pavlou -- Protein Quantification by Mass Spectrometry / Andrei P. Drabovich / Eleftherios P. Diamandis / Ihor Batruch / Maria P. Pavlou -- Biomarker Verification / Andrei P. Drabovich / Eleftherios P. Diamandis / Ihor Batruch / Maria P. Pavlou -- Biomarker Validation / Andrei P. Drabovich / Eleftherios P. Diamandis / Ihor Batruch / Maria P. Pavlou --
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| 505 |
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|a Acknowledgments / Josip Blonder / Xiaoying Ye / Bih-Rong Wei / King C. Chan / Darue A. Prieto -- References / Xiaoying Ye / Darue A. Prieto / Josip Blonder / Bih-Rong Wei / King C. Chan -- Abbreviations / Dajana Vuckovic -- Introduction / Dajana Vuckovic -- An Ideal Sample Preparation Method for Global Metabolomics? / Dajana Vuckovic -- Sample Preparation Methods for Biofluids / Dajana Vuckovic -- Tissue Metabolomics / Dajana Vuckovic -- New Trends in Sample Preparation for Global Metabolomics / Dajana Vuckovic -- Conclusions and Future Perspective / Dajana Vuckovic -- Acknowledgments / Dajana Vuckovic -- References / Dajana Vuckovic -- Introduction / Melissa Tuck / Dean E. Brenner / D. Kim Turgeon -- Importance of Preanalytical Variables / Melissa Tuck / Dean E. Brenner / D. Kim Turgeon -- Standard Operating Procedures (SOPs) / Melissa Tuck / Dean E. Brenner / D. Kim Turgeon -- Sample Selection Considerations / Melissa Tuck / Dean E. Brenner / D. Kim Turgeon --
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| 505 |
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|a Why NMR? / Que N. Van -- NMR Hardware Advancement / Que N. Van -- Sample Preparation for NMR Analysis / Que N. Van -- One-Dimensional NMR Methods: 1H, 13C, 31P / Que N. Van -- 2D Methods / Que N. Van -- Targeted Metabolic Profiling / Que N. Van -- High-Resolution Magic Angle Spinning (HR-MAS) NMR Spectroscopy / Que N. Van -- Magnetic Resonance Spectroscopy (MRS) / Que N. Van -- NMR Data Processing and Preparation for Statistical Analysis / Que N. Van -- NMR Metabolite Identification / Que N. Van
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| 505 |
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|a Historical Perspective / Timothy D. Veenstra / Haleem J. Issaq --
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| 505 |
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|a Microwave-Supported Asp-Selective Acid Proteolysis / Joe R. Cannon / Catherine Fenselau -- Methods Development with Microwave-Supported Acid Hydrolysis / Joe R. Cannon / Catherine Fenselau -- Applications of Microwave-Supported Acid Hydrolysis / Joe R. Cannon / Catherine Fenselau -- Advantages and Disadvantages of Microwave-Supported Asp-Selective Acid Proteolysis / Joe R. Cannon / Catherine Fenselau -- References / Joe R. Cannon / Catherine Fenselau -- Introduction / Haleem J. Issaq / Timothy D. Veenstra -- Depletion / Haleem J. Issaq / Timothy D. Veenstra -- Fractionation Procedures for Proteins and Metabolites / Haleem J. Issaq / Timothy D. Veenstra -- Affinity Chromatography / Timothy D. Veenstra / Haleem J. Issaq -- Isoelectric Focusing / Timothy D. Veenstra / Haleem J. Issaq -- Size Exclusion Chromatography / Timothy D. Veenstra / Haleem J. Issaq -- Conclusions / Timothy D. Veenstra / Haleem J. Issaq -- References / Timothy D. Veenstra / Haleem J. Issaq --
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| 505 |
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|a Integrated Biomarker Discovery Platform / Andrei P. Drabovich / Eleftherios P. Diamandis / Ihor Batruch / Maria P. Pavlou -- References / Andrei P. Drabovich / Eleftherios P. Diamandis / Ihor Batruch / Maria P. Pavlou -- Introduction / Xiaoying Ye / Darue A. Prieto / Josip Blonder / Bih-Rong Wei / King C. Chan -- Types of Tissues Available for MS-Based Proteomics / Xiaoying Ye / Darue A. Prieto / Josip Blonder / Bih-Rong Wei / King C. Chan -- Tissue Disruption/Homogenization / Xiaoying Ye / Darue A. Prieto / Josip Blonder / Bih-Rong Wei / King C. Chan -- Extraction/Solubilization Buffers / Xiaoying Ye / Darue A. Prieto / Josip Blonder / Bih-Rong Wei / King C. Chan -- Concluding Remarks / Xiaoying Ye / Darue A. Prieto / Josip Blonder / Bih-Rong Wei / King C. Chan --
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| 505 |
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|a Two-Dimensional Differential In-Gel Electrophoresis / Haleem J. Issaq / Timothy D. Veenstra -- Strengths and Weaknesses of 2D-PAGE and 2D-DIGE / Haleem J. Issaq / Timothy D. Veenstra -- Application of 2D-DIGE to Biomarker Discovery / Haleem J. Issaq / Timothy D. Veenstra -- Conclusions / Timothy D. Veenstra / Haleem J. Issaq -- Acknowledgments / Timothy D. Veenstra / Haleem J. Issaq -- References / Haleem J. Issaq / Timothy D. Veenstra -- Introduction / Fred E. Regnier / Wonryeon Cho -- Affinity Targeting Methods / Wonryeon Cho / Fred E. Regnier -- Single Gene Expression Product Selection / Fred E. Regnier / Wonryeon Cho -- Post-Translational Modifications / Fred E. Regnier / Wonryeon Cho -- Abundant Protein Removal / Fred E. Regnier / Wonryeon Cho -- Conclusions / Wonryeon Cho / Fred E. Regnier -- References / Wonryeon Cho / Fred E. Regnier -- Introduction / Joe R. Cannon / Catherine Fenselau -- Aspartate-Selective Acid Proteolysis / Joe R. Cannon / Catherine Fenselau --
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| 505 |
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|a Future Directions and Conclusion / Que N. Van -- References / Que N. Van -- Introduction / David R. Goodlett / Young Ah Goo -- PAcIFIC and Quantification / David R. Goodlett / Young Ah Goo -- Proteome Profiling with PAcIFIC / David R. Goodlett / Young Ah Goo -- Perspectives / Young Ah Goo / David R. Goodlett -- References / David R. Goodlett / Young Ah Goo -- Introduction / Eric Chun Yong Chan / Lian Yee Yip -- GC/MS in Metabonomics / Eric Chun Yong Chan / Lian Yee Yip -- Strategies to Address Large-Scale Metabonomic Investigations / Eric Chun Yong Chan / Lian Yee Yip -- Conclusion and Future Outlook / Eric Chun Yong Chan / Lian Yee Yip -- References / Eric Chun Yong Chan / Lian Yee Yip -- Introduction / Georgios A. Theodoridis / Ian D. Wilson / Robert Plumb / Helen G. Gika -- Chromatographic Methods for Metabolite Profiling / Georgios A. Theodoridis / Ian D. Wilson / Robert Plumb / Helen G. Gika -- Detection / Georgios A. Theodoridis / Ian D. Wilson / Robert Plumb / Helen G. Gika -
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| 505 |
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|a Abbreviations / Haleem J. Issaq / Timothy D. Veenstra -- Introduction / Haleem J. Issaq / Timothy D. Veenstra -- Definitions / Timothy D. Veenstra / Haleem J. Issaq -- The Current State of Biomarker Discovery / Timothy D. Veenstra / Haleem J. Issaq -- Study Design and Execution / Timothy D. Veenstra / Haleem J. Issaq -- Errors in Study Design / Haleem J. Issaq / Timothy D. Veenstra -- Errors in Study Execution / Timothy D. Veenstra / Haleem J. Issaq -- Specificity of Proteins as Biomarkers / Haleem J. Issaq / Timothy D. Veenstra -- Statistical Data Analysis / Timothy D. Veenstra / Haleem J. Issaq -- Recommendations / Haleem J. Issaq / Timothy D. Veenstra -- Concluding Remarks and Recommendations / Timothy D. Veenstra / Haleem J. Issaq -- Acknowledgments / Haleem J. Issaq / Timothy D. Veenstra -- References / Timothy D. Veenstra / Haleem J. Issaq -- Introduction / Maria P. Pavlou / Ihor Batruch / Eleftherios P. Diamandis / Andrei P. Drabovich --
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| 653 |
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|a MEDICAL / Lasers in Medicine / bisacsh
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| 653 |
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|a MEDICAL / Biotechnology / bisacsh
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| 653 |
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|a Metabolism / Regulation
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| 653 |
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|a Metabolomics / methods
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| 653 |
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|a Molecular Biology
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| 653 |
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|a MEDICAL / Allied Health Services / Medical Technology / bisacsh
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| 653 |
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|a Biological Markers
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| 653 |
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|a TECHNOLOGY & ENGINEERING / Biomedical / bisacsh
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| 653 |
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|a Proteomics
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| 653 |
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|a Proteomics / methods
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| 653 |
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|a Biochemical markers
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| 653 |
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|a Proteomics / fast / (OCoLC)fst01079785
|
| 653 |
|
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|a MEDICAL / Family & General Practice / bisacsh
|
| 653 |
|
|
|a Biochemical Markers
|
| 653 |
|
|
|a Biochemical markers / fast / (OCoLC)fst00831950
|
| 700 |
1 |
|
|a Veenstra, Timothy Daniel
|
| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
|
| 989 |
|
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|b ESD
|a Elsevier ScienceDirect eBooks
|
| 856 |
4 |
0 |
|u http://www.sciencedirect.com/science/book/9780123944467
|x Verlag
|3 Volltext
|
| 082 |
0 |
|
|a 610.28
|
| 520 |
|
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|a Proteomic and Metabolomic Approaches to Biomarker Discovery demonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including techniques used in proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes. Proteomic and Metabolomic Approaches to Biomarker Discovery is the only publication that covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods, and presents a standard operating procedure for sample selection, preparation, and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. A vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals, and graduate students, Proteomic and Metabolomic Approaches to Biomarker Discovery provides the information needed to reduce clinical error in the execution of research. Describes the use of biomarkers to reduce clinical errors in research. Includes techniques from a range of biomarker discoveries. Covers all steps involved in biomarker discovery, from study design to study execution
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