Treatment of metastatic non-small cell lung cancer a systematic review of comparative effectiveness and cost-effectiveness

Lung cancer is the leading cause of cancer death in both men and women in the United States, and male Veterans seeking care at VA hospitals have a much higher age-specific incidence of lung cancer than males in the general population. The personal and economic significance of lung cancer has led to...

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Bibliographic Details
Main Authors: Shekelle, Paul G., Ruelaz Maher, Alicia (Author)
Corporate Authors: United States Department of Veterans Affairs, West Los Angeles VA Medical Center Evidence-Based Synthesis Program Center, Quality Enhancement Research Initiative (U.S.)
Format: eBook
Language:English
Published: Washington, DC Department of Veterans Affairs, Health Services Research & Development Service [2012], 2012
Series:Evidence-based synthesis program
Subjects:
Online Access:
Collection: National Center for Biotechnology Information - Collection details see MPG.ReNa
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100 1 |a Shekelle, Paul G. 
245 0 0 |a Treatment of metastatic non-small cell lung cancer  |h Elektronische Ressource  |b a systematic review of comparative effectiveness and cost-effectiveness  |c prepared for, Department of Veterans Affairs, Veterans Health Administration, Quality Enhancement Research Initiative, Health Services Research & Development Service ; prepared by, Evidence-based Synthesis Program (ESP) Center, West Los Angeles VA Medical Center ; principal investigators, Paul G. Shekelle, Alicia R. Maher ; research associates, Isomi M. Miake-Lye, Jessica M. Beroes 
260 |a Washington, DC  |b Department of Veterans Affairs, Health Services Research & Development Service  |c [2012], 2012 
300 |a 1 PDF file (iv, 82 pages) 
505 0 |a Includes bibliographical references 
653 |a Comparative Effectiveness Research 
653 |a Lung Neoplasms / drug therapy 
653 |a Cost-Benefit Analysis 
653 |a Carcinoma, Non-Small-Cell Lung / drug therapy 
700 1 |a Ruelaz Maher, Alicia  |e [author] 
710 2 |a United States  |b Department of Veterans Affairs 
710 2 |a West Los Angeles VA Medical Center  |b Evidence-Based Synthesis Program Center 
710 2 |a Quality Enhancement Research Initiative (U.S.) 
041 0 7 |a eng  |2 ISO 639-2 
989 |b NCBI  |a National Center for Biotechnology Information 
490 0 |a Evidence-based synthesis program 
500 |a Title from PDF cover. - "October 2012." 
856 4 0 |u https://www.ncbi.nlm.nih.gov/books/NBK153078  |3 Volltext  |n NLM Bookshelf Books  |3 Volltext 
082 0 |a 610 
520 |a Lung cancer is the leading cause of cancer death in both men and women in the United States, and male Veterans seeking care at VA hospitals have a much higher age-specific incidence of lung cancer than males in the general population. The personal and economic significance of lung cancer has led to a vast research endeavor to try and identify new and more effective treatments. Most patients with lung cancer are diagnosed when the cancer is already advanced (stage IIIB or IV), and they are no longer candidates for surgical resection. Small cell lung cancer and non-small cell lung cancer (NSCLC) are different diseases in terms of treatment. Until recently, all therapies for advanced NSCLC were based on their cytotoxic properties. In the last few years, several novel agents aimed at specific molecular targets have been developed. This review was requested to evaluate the current evidence on the effectiveness and cost-effectiveness of treatments for advanced lung cancer