Mass Spectrometry Imaging of Small Molecules

Mass Spectroscopy Imaging (MSI) has emerged as an enabling technique to provide insight into the molecular entities within cells, tissues and whole-body samples and to understand inherent complexities within biological metabolomes. In Mass Spectrometry Imaging of Small Molecules, experts in the MSI...

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Bibliographic Details
Other Authors: He, Lin (Editor)
Format: eBook
Language:English
Published: New York, NY Springer New York 2015, 2015
Edition:1st ed. 2015
Series:Methods in Molecular Biology
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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245 0 0 |a Mass Spectrometry Imaging of Small Molecules  |h Elektronische Ressource  |c edited by Lin He 
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505 0 |a Current Status and Future Prospects of Mass Spectrometry Imaging of Small Molecules -- Sample Preparation for 3D SIMS Chemical Imaging of Cells -- TOF-SIMS Imaging of Lipids on Rat Brain Sections -- MALDI-MS Assisted Molecular Imaging of Metabolites in Legume Plants -- MALDI Mass Spectrometry Imaging of Lipids and Primary Metabolites on Rat Brain Sections -- Multiplex MALDI-MS Imaging of Plant Metabolites Using a Hybrid MS System -- DESI Imaging of Small Molecules in Biological Tissues -- Desorption Electrospray Ionization Imaging of Small Organics on Mineral Surfaces -- Imaging of Plant Materials Using Indirect Desorption Electrospray Ionization Mass Spectrometry -- Imaging of Lipids and Metabolites Using Nanospray Desorption Electrospray Ionization Mass Spectrometry -- Electrospray Laser Desorption Ionization (ELDI) Mass Spectrometry for Molecular Imaging of Small Molecules on Tissues -- Automated Cell-By-Cell Tissue Imaging and Single Cell Analysis for Targeted Morphologies by Laser Ablation Electrospray Ionization Mass Spectrometry -- Laser Ablation Sample Transfer for Mass Spectrometry Imaging -- Nanostructure-Based Mass Spectrometry: High Sensitivity, Enzyme Activity Analysis and Metabolite Imaging -- Nanostructure-Initiator Mass Spectrometry (NIMS) for Molecular Mapping of Animal Tissues -- Nanoparticle-Assisted Laser Desorption/Ionization for Metabolite Imaging.-Matrix-Enhanced Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (ME-SALDI-MS) for Mass Spectrometry Imaging of Small Molecules -- Laser Desorption Postionization Mass Spectrometry Imaging of Biological Targets -- Data Processing and Analysis for Mass Spectrometry Imaging 
653 |a Biological Microscopy 
653 |a Spectroscopy 
653 |a Radiology 
653 |a Imaging / Radiology 
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520 |a Mass Spectroscopy Imaging (MSI) has emerged as an enabling technique to provide insight into the molecular entities within cells, tissues and whole-body samples and to understand inherent complexities within biological metabolomes. In Mass Spectrometry Imaging of Small Molecules, experts in the MSI field present techniques for 2D and 3D visualization and quantification of a wide array of small molecular species present in biologically relevant samples. Chapters provide detailed operational instructions from sample preparation to method selection, from comparative quantification to structural identification, and from data collection to visualization of small molecule mapping in complex samples. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Mass Spectrometry Imaging of Small Molecules aims to bring the rapidly maturing methods of metabolic imaging to life science researchers and to minimize technical intimidation in adapting new technological platforms in biological research