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Molecular Genetics of Dysregulated pH Homeostasis

Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological function at every level, including protein folding, enzymatic activities and proliferation, and cell death. Therefore, maintaining the pH homeostasis at the local or...

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Bibliographic Details
Other Authors: Chi, Jen-Tsan Ashley (Editor)
Format: eBook
Language:English
Published: New York, NY Springer New York 2014, 2014
Edition:1st ed. 2014
Subjects:
Cell Biology
Medical Genetics
Medicine / Research
Cytology
Biology / Research
Biomedical Research
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Molecular Genetics of Acid Sensing and Response
  • Part I: Sensing Acidity
  • The molecular mechanism of cellular sensing of acidity
  • The Molecular Basis of Sour Sensing in Mammals
  • Function and Signaling of the pH-sensing G protein-coupled receptors in physiology and diseases
  • Part II: Response to Acidity
  • The MondoA-TXNIP checkpoint couples the acidic tumor microenvironment to cell metabolism
  • Regulation of Renal Glutamine Metabolisms during Metabolic Acidosis
  • Extracellular acidosis and cancer
  • The genomic analysis of cellular responses and adaptions to extracellular acidosis
  • Index

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