Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain

ATP was naturally selected very early on as the main source of biological energy, and thus became an indispensable feature of life on the Earth. This was a critical evolutionary choice because it shaped enzymatic systems to utilize ATP in energy-dependent reactions and necessitated an appearance of...

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Bibliographic Details
Other Authors: Parpura, Vladimir (Editor), Schousboe, Arne (Editor), Verkhratsky, Alexei (Editor)
Format: eBook
Language:English
Published: Cham Springer International Publishing 2014, 2014
Edition:1st ed. 2014
Series:Advances in Neurobiology
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • 1. Glutamate and ATP: The Crossroads of Signaling and Metabolism in the Brain
  • 2. Glutamate Metabolism in the Brain Focusing on Astrocytes
  • 3. Glycogenolysis and Purinergic Signaling
  • 4. Purinergic and Glutamatergic Receptors on Astroglia
  • 5. Regulated Exocytosis in Astrocytes Is as Slow as the Metabolic Availability of Gliotransmitters: Focus on Glutamate and ATP
  • 6. Adenosine and Glutamate in Neuroglial Interaction: Implications for Circadian Disorders and Alcoholism
  • 7. Purinergic Receptor Stimulation Decreases Ischemic Brain Damage By Energizing Astrocyte Mitochondria
  • 8. Excitotoxicity and Mitochondrial Dysfunction Underlie Age-dependent Ischemic White Matter Injury
  • 9. Role of Astrocytes in Delayed Neuronal Death: GLT-1 and its Novel Regulation by MicroRNAs
  • 10. Ca2+ Signaling in Astrocytes and its Role in Ischemic Stroke
  • 11. Pathological Potential of Astroglial Purinergic Receptors