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02154nmm a2200313 u 4500 |
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140303 ||| eng |
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|a 9783642543043
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|a Gong, Jianxian
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|a Total Synthesis of (±)-Maoecrystal V
|h Elektronische Ressource
|c by Jianxian Gong
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|a 1st ed. 2014
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| 260 |
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|a Berlin, Heidelberg
|b Springer Berlin Heidelberg
|c 2014, 2014
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| 300 |
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|a XII, 137 p. 177 illus., 1 illus. in color
|b online resource
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|a Research Background for Natural Product Maoecrystal V and Its Family -- The Model Study of Natural Product Maoecrystal V -- The total synthesis study of Maoecrystal V -- Summary
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| 653 |
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|a Catalysis
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| 653 |
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|a Medicinal chemistry
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| 653 |
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|a Chemistry, Organic
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| 653 |
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|a Medicinal Chemistry
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| 653 |
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|a Organic Chemistry
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| 041 |
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7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b Springer
|a Springer eBooks 2005-
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| 490 |
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|a Springer Theses, Recognizing Outstanding Ph.D. Research
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|a 10.1007/978-3-642-54304-3
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|u https://doi.org/10.1007/978-3-642-54304-3?nosfx=y
|x Verlag
|3 Volltext
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|a 547
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|a In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereoselective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures
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