Mucosal Delivery of Biopharmaceuticals Biology, Challenges and Strategies

This book provides a concise and up-to-date overview of the biological features justifying the use of different human mucosa as delivery routes for biopharmaceuticals as well as the technological strategies that have been followed so far regarding the optimization of mucosal potentialities. The book...

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Bibliographic Details
Other Authors: das Neves, José (Editor), Sarmento, Bruno (Editor)
Format: eBook
Published: New York, NY Springer US 2014, 2014
Edition:1st ed. 2014
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Concepts in Mucosal Immunity and Mucosal Vaccines
  • Mucoadhesion and Characterization of Mucoadhesive Properties
  • Mucus as a Barrier for Biopharmaceuticals and Drug Delivery Systems
  • Epithelial Permeation and Absorption Mechanisms of Biopharmaceuticals
  • Oral Delivery of Biopharmaceuticals
  • Buccal Delivery of Biopharmaceuticals: Vaccines and Allergens
  • Pulmonary Delivery of Biopharmaceuticals
  • Nasal Delivery of Biopharmaceuticals
  • Ocular Delivery of Biopharmaceuticals
  • Vaginal Delivery of Biopharmaceuticals
  • Nanoparticles-in-Microsphere Oral Delivery Systems (NiMOS) for Nucleic Acid Therapy in the Gastrointestinal Tract
  • Bacteria-Based Vectors for Oral Gene Therapy
  • Self-Assembled Polysaccharide Nanogels for Nasal Delivery of Biopharmaceuticals
  • Pheroid™ Vesicles and Microsponges for Nasal Delivery of Biopharmaceuticals
  • Delivery Strategies for Developing siRNA-Based Vaginal Microbicides
  • Delivery Strategies for Developing Vaginal DNA Vaccine Combining Cell-Penetrating Peptides and Jet Injection
  • Vaccine Delivery Systems for Veterinary Immunization
  • Eligen® Technology for Oral Delivery of Proteins and Peptides
  • The RapidMist™ System for Buccal Delivery of Insulin
  • The Pharmaceutical Development of rhDNase (Dornase Alpha) for the Treatment of Cystic Fibrosis
  • Development of the Exubera® Insulin Pulmonary Delivery System
  • Technosphere®: An Inhalation System for Pulmonary Delivery of Biopharmaceuticals
  • ChiSys® as a Chitosan-Based Delivery Platform for Nasal Vaccination
  • Development of a Cationic Nanoemulsion Platform (Novasorb®) for Ocular Delivery
  • Regulatory Aspects and Approval of Biopharmaceuticals for Mucosal Delivery: Quality, Toxicology and Clinical Aspects