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Transition Metal Complexes as Drugs and Chemotherapeutic Agents

When this book was first conceived as a project the expanding interest in the clinical use of platinum and gold complexes made a survey of the relevant biological properties of metal complexes timely and appropriate. This timeliness has not diminished during the gestation and final publica­ tion of...

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Bibliographic Details
Main Author: Farrell, N.
Format: eBook
Language:English
Published: Dordrecht Springer Netherlands 1989, 1989
Edition:1st ed. 1989
Series:Catalysis by Metal Complexes
Subjects:
Inorganic Chemistry
Pharmacy
Organometallic Chemistry
Organometallic Chemistry 
Oncology
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • 6. Antitumour Activity of Metal Complexes
  • 6.1. Platinum Group Metal Complexes
  • 6.2. Copper Complexes
  • 6.3. Silver and Gold
  • 6.4. Organometallic Complexes
  • 6.5. Summary
  • References
  • 7. Metal-Mediated Antibiotic Action
  • 7.1. Discovery and Pharmacology of Bleomycin
  • 7.2. Structure of Bleomycin and Analogues
  • 7.3. Metal Complexes of Bleomycin
  • 7.4. Mechanism of Action of Bleomycin
  • 7.5. Other Metal Binding Antibiotics
  • 7.6. Summary
  • References
  • 8. Metals, Metal Complexes, and Radiation
  • 8.1. Interaction of Radiation and Biological Tissue
  • 8.2. Chemical Modification of Radiation Damage
  • 8.3. Metal Complexes as Radiation Sensitizers
  • 8.4. Metal Complexes and Radioprotection
  • 8.5. Activation of Metal Complexes
  • 8.6. Summary
  • References
  • 9. Antibacterial Effects of Metal Complexes
  • 9.1. Mercury and Silver Salts as Antibacterial Agents
  • 9.2. Antibacterial Activity of Chelating Agents and Metal Chelates
  • Metals in Medicine
  • Chemotherapeutic Agents and Drugs
  • Mechanisms of Toxicity
  • Metal Accumulation and Activation
  • Biochemical Targets for Metal Complexes
  • Summary
  • References
  • 1. Interaction of Metal Complexes with DNA
  • 1.1. DNA and Conformation
  • 1.2. Experimental Methods for the Study of Conformational Changes
  • 1.3. Binding of Metal Complexes to DNA
  • 1.4. Summary
  • References
  • 2. Platinum—Amine Complexes as Anticancer Agents
  • 2.1. The Discovery of Cisplatin as an Antitumour Agent
  • 2.2. Clinical Properties of Cisplatin
  • 2.3. Development of Cisplatin Analogues
  • 2.4. Biochemical Mechanism of Action of Platinum Complexes
  • 2.5. Summary
  • References
  • 3. Structure—Activity Relationships of Platinum— Amine Complexes
  • 3.1. The Requirement for Neutrality
  • 3.2. Complexes of Pt(IV)
  • 3.3. Nature of the Leaving Group
  • 3.4. Nature of the Nonleaving Group
  • 3.5. Novel and Targeted Approaches to [PtX2(am)2] Complexes
  • 3.6. Quantitative Structure—Activity Relationships
  • 3.7. Chemistry of Platinum—Amine Complexes
  • 3.8. Summary
  • References
  • 4. Interactions of Platinum Complexes with DNA Components
  • 4.1. Structural Aspects of Metal—Nucleobase Binding
  • 4.2. Reactivity of Platinum Metal—Base Complexes
  • 4.3. Solid State Structural Studies
  • 4.4. Structural Studies on Di- and Oligonucleotide Complexes
  • 4.5. Platinum Adducts from DNA Degradation
  • 4.6. On the Molecular Mechanism of Antitumour Action of Cisplatin
  • 4.7. Summary
  • References
  • 5. The Platinum—Pyrimidine Blues
  • 5.1. Properties of the Platinum—Pyrimidine Blues
  • 5.2. Platinum Blues not Derived from Pyrimidines
  • 5.3. X-Ray Structure of Platinum—Pyrimidine and ?-Pyridone Blues
  • 5.4. Formation of Platinum—Pyrimidine and ?-Pyridone Blues
  • 5.5. Studies of Crystalline Blues.-5.6. Biological Studies on Platinum—Pyrimidine Blue Precursors
  • 5.7. Summary
  • References
  • 9.3. Antibacterial Activity of Metal—Amine Complexes
  • 9.4. Redox Activity and Antibacterial Activity
  • 9.5. Summary
  • References
  • 10. Antiviral and Antiparasitic Effects of Metal Complexes
  • 10.1. Antiviral Therapy
  • 10.2. Chelating Agents and Metal Complexes as Antiviral Agents
  • 10.3 Metal Complexes as Antiprotozoal Agents
  • 10.4. Summary
  • References
  • 11 Metal Complexes in Arthritis
  • 11.1. Gold Complexes in the Treatment of Rheumatoid Arthritis
  • 11.2. Copper in Arthritis
  • 11.3. Other Metals
  • 11.4. Summary
  • References
  • 12. Miscellaneous Uses of Metal Complexes
  • 12.1. Mercurial Diuretics
  • 12.2. Neuromuscular Effects of Metal Complexes
  • 12.3. Nitroprusside as Vasodilator
  • 12.4. Summary
  • References
  • Names and Abbreviations
  • Glossary of Termsand Definitions
  • Appendix 1
  • Appendix 2
  • Index of Subjects

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