Statistics Applied to Clinical Trials
In 1948 the first randomized controlled trial was published by the English Medical Research Council in the British Medical Journal. Until then, observations had been uncontrolled. Initially, trials frequently did not confirm hypotheses to be tested. This phenomenon was attributed to low sensitivity...
| Main Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
Dordrecht
Springer Netherlands
2002, 2002
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| Edition: | 2nd ed. 2002 |
| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- Preface
- Foreword
- 1. Hypotheses, Data, Stratification
- 2. The analysis of efficacy data of drug trials
- 3. The analysis of safety data of drug trials
- 4. Equivalence testing
- 5. Statistical power and sample size
- 6. Interim analysis
- 7. Multiple statistical inferences
- 8. Principles of linear regression
- 9. Subgroup analysis multiple linear regression: confounding, interaction, synergism
- 10. Curvilinear regression
- 11. Meta-analysis
- 12. Crossover studies with continuous variables: power analysis
- 13. Crossover studies with binary responses
- 14. Post-hoc analysis in clinical trials, a case for logistic regression analysis
- 15. quality-of-life assessment in clinical trials
- 16. Statistics for the analysis of genetic data
- 17. Relationship among statistical distributions
- 18. Statistics is not "bloodless" algebra
- Appendix
- Index