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Dietary Fats, Prostanoids and Arterial Thrombosis

Knowledge of mechanisms involved in the pathogenesis of occlusive arterial dis­ eases is fundamental for the design of prevention and treatment. A series of studies based on in vitro investigations, the experimental animal and the human being have slowly increased our understanding of cardiovascular...

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Bibliographic Details
Main Author: Hornstra, G.
Format: eBook
Language:English
Published: Dordrecht Springer Netherlands 1982, 1982
Edition:1st ed. 1982
Series:Developments in Hematology and Immunology
Subjects:
Hematology
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • 1. Arterial Thrombosis, Platelets and Atherogenesis
  • 1.1. Pathology of arterial thrombosis
  • 1.2. Thrombosis and atherogenesis
  • 1.3. The platelet-derived growth factor and atherogenesis
  • 2. Biochemical Physiology of Dietary Fats
  • 2.1. Structure and nomenclature of fatty acids
  • 2.2. Fatty acids synthesis
  • 2.3. Essential fatty acids
  • 2.4. Fatty acid degradation
  • 2.5. Fatty acid derivatives
  • 2.6. Fat absorption
  • 2.7. Plasmatic transport of fatty acids
  • 2.8. Functions of fatty acids
  • 2.9. Lipid metabolism of platelets
  • 3. The Role of Prostanoids in Arterial Thromboregulation
  • 3.1. Introduction
  • 3.2. Platelet prostaglandins and thromboxanes
  • 3.3. Vascular prostaglandins
  • 3.4. Prostanoid biosynthesis and metabolism
  • 3.5. Interaction between platelet and vascular prostanoids
  • 3.6. Functional significance of prostanoids in haemostasis and thrombosis
  • 3.7. Prostanoid mechanisms of action
  • 3.8. Prostanoids of the 1- and 3-series
  • 8.5. Relationship between the arachidonic acid content of platelet phospholipids and the HHT production of activated platelets
  • 8.6. Possible consequences of platelet lipid profile and fatty acid composition for membrane fluidity
  • 8.7. Summary
  • 9. Effect of Dietary Linoleic Acid on Platelet Function in Man
  • 9.1. Introduction
  • 9.2. Methods
  • 9.3. Results
  • 9.4. Discussion
  • 9.5. The long-term thromboprotective effect of dietary linoleic acid
  • 9.6. Possible mechanisms by which linoleic acid lowers platelet aggregability and arterial thrombosis tendency
  • 9.7. Summary
  • 10. Summary and Concluding Remarks
  • References
  • 4. Effect of Type and Amount of Dietary Fats on Arterial Thrombus Formation
  • 4.1. Introduction
  • 4.2. Dietary fats and arterial thrombosis: a literature survey
  • 4.3. New experimental model of arterial thrombosis in rats
  • 4.4. Relationship between dietary fatty acid composition and arterial thrombosis tendency in rats
  • 4.5. Summary
  • 5. Location of Dietary Fat Effect on Arterial Thrombus Formation
  • 5.1. Introduction
  • 5.2. Effect of sunflowerseed oil (SO) and hydrogenated coconut oil (HCO) on blood coagulation
  • 5.3. Effect of the dietary fat type on platelet aggregability
  • 5.4. Possible mechanisms by which dietary fats affect platelet aggregation and arterial thrombus formation
  • 5.5. Summary
  • 6. The Significance of Prostanoids in the Dietary Fat Effects on Arterial Thrombogenesis
  • 6.1. Introduction
  • 6.2. Arterial thrombusformation in essential fatty acid deficiency
  • 6.3. Effect of dietary fats on platelet and vascular prostanoid formation
  • 6.4. General summary
  • 7. Effect of Fish Oil Feeding on Arterial Thrombosis, Platelet Function and Blood Coagulation
  • 7.1. Introduction
  • 7.2. Effect of dietary fish oil on arterial thrombus formation in rats
  • 7.3. Bleeding time: comparison between the effect of dietary fish oils and sunflowerseed oil
  • 7.4. Effect of dietary fish oils on platelet aggregation
  • 7.5. The effect of fish oil feeding on some coagulation parameters
  • 7.6. Effect of fish oil feeding on platelet thromboxane production and the vascular formation of prostacyclin-like material
  • 7.7. Fish oil feeding and formation of prostanoids of the 3-series
  • 7.8. General discussion
  • 7.9. Summary
  • 8. Relationship between Dietary Fat Type, Platelet Fatty Acid Composition and Eicosanoid Formation by Activated Platelets
  • 8.1. Introduction
  • 8.2. Experimental procedure
  • 8.3. HHT and HETE production of collagen-activated blood platelets
  • 8.4. Platelet phospholipid analysis

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