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LHRH and Its Analogs Contraceptive and Therapeutic Applications Part 2

Since the discovery of LHRH in 1971, research into the physiology and therapeutics of this compound can be divided into three dis­ tinctly different phases. In the first phase, attention was paid chiefly to the natural sequence hormone; efforts were channeled to explore its diagnostic use; and nearl...

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Bibliographic Details
Other Authors: Vickery, B.H. (Editor), Nestor, J.J. (Editor)
Format: eBook
Language:English
Published: Dordrecht Springer Netherlands 1987, 1987
Edition:1st ed. 1987
Subjects:
Gynecology
Gynecology 
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • Section 1 Chemistry
  • 1. Development of LHRH antagonists
  • 2. LHRH antagonists with low histamine releasing activity
  • 3. Specificity of design to achieve antagonists of LHRH of increasing effectiveness in therapeutic activity
  • 4. Biosynthesis of LHRH
  • 5. Phylogenetic diversity of LHRH
  • Section 2 Mechanisms of Action of Hypothalamic LHRH and Analogs
  • 6. Molecular mechanism of LHRH action in the gonadotrope
  • 7. Mediation of the preovulatory LH surge: LHRH pulsatility and opioid modulation
  • Section 3 Extra-Hypothalamic LHRH-Like Materials
  • 8. LHRH binding sites in human tissues
  • 9. LHRH and “LHRH-like” factors in the male reproductive tract
  • 10. Placental LHRH-like activity
  • Section 4 Pharmacology of LHRH Antagonists
  • 11. In vitro histamine release with LHRH analogs
  • 12. Anaphylactoid properties of LHRH analogs
  • 13. Reproductive physiology and general pharmacology of LHRH antagonists
  • 27. Intermittent LHRH agonist sequentially combined with a progestogen as antiovulatory contraception
  • 28. LHRH agonists and male contraception
  • Section 7 Gonadal Protective Prospects with LHRH Analogs
  • 29. Interactions between an LHRH analogue and cancer chemotherapeutic agents at the testicular level in dogs
  • 30. Is it possible to conserve the fertility of patients with Hodgkin’s disease treated with cytotoxic chemotherapy?
  • Section 8 Diagnostic Applications
  • 31. Predicting predisposition to osteoporosis: GnRH antagonist for acute estrogen deficiency
  • Section 9 Applications in Animals
  • 32. The use of LHRH analogs in aquaculture
  • 33. Uses of LHRH and its analogs in cattle
  • 34. Clinical uses of LHRH analogs in dogs
  • Section 10 Formulation and Metabolism
  • 35. Intra-nasal administration of LHRH and its analogs
  • 36. The controlled delivery of polypeptides including LHRH analogs
  • 37. Pharmacokinetics and metabolism of LHRH analogs
  • Epilogue
  • 14. Suppression of plasma gonadotropins, testosterone and sperm production in adult male monkeys by a potent inhibitory analog of LHRH
  • 15. LHRH antagonists and female reproductive function
  • Section 5 Basic Clinical Studies
  • 16. LHRH antagonists in normal men
  • 17. Clinical investigations of the contraceptive and therapeutic potential of nafarelin
  • 18. LHRH agonists and antagonists: therapeutic possibilities for premenstrual syndrome
  • 19. Early clinical studies with LHRH antagonists in women
  • 20. Profertility uses of LHRH agonist analogues
  • Section 6 Clinical Trials
  • 21. Ovulation induction with pulsatile LHRH
  • 22. Treatment of endometriosis by nasal administration of nafarelin
  • 23. Effects of nafarelin in precocious puberty
  • 24. Pharmacokinetics, metabolism and clinical studies with buserelin
  • 25. Trials with leuprolide
  • 26. Zoladex studies in prostatic andbreast cancer

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