The Enigma of Slow Viruses Facts and Artefacts
Scrapie, a naturally occurring neurodegenerative disease of sheep and sometimes goats, is a prototypic disease for the whole group of the subacute spongiform virus encephalopathies. Kuru was the first human disease of this type to be discovered in 1957 by Gajdusek and Zigas, and its discovery opened...
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| Format: | eBook |
| Language: | English |
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Vienna
Springer Vienna
1993, 1993
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| Edition: | 1st ed. 1993 |
| Series: | Archives of Virology. Supplementa
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| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- 1. Introduction: subacute spongiform virus encephalopathies from the perspective of a neuroscientist
- 2. The molecular biology of the slow viruses
- 2.1. The search for the virus-specific nucleic acid
- 2.2. The prion protein
- 2.3. The structure of the gene encoding PrP 33-35 (Prn-p) in different species
- 2.4. The models of slow viruses
- 3. The pathogenesis of slow virus infection
- 3.1. The general sequence of the pathogenetic events
- 3.2. The role of the spleen
- 3.3. The role of the spleen in neuroinvasion
- 3.4. The role of viremia
- 3.5. The role of macrophages in scrapie infection
- 3.6. The neural spread of infectivity from the spleen to the central nervous system
- 3.7. The neural spread of infectivity within the central nervous system
- 3.8. Biochemistry and histochemistry of slow virus infections
- 4. Neuropathology of slow virus diseases Ill
- 4.1. Natural scrapie
- 4.2. Kuru
- 4.3. Creutzfeldt-Jakob disease (CJD)
- 4.4. Elements of neuropathology of slow virus disorders
- 5. Final conclusions
- Addendum
- References