Regulation of Aldosterone Biosynthesis
Most of our knowledge of the physiological control of aldosterone secretion is based on animal experiments and clinical studies which were carried out in the 1950s and early 1960s by a large number of inspired, ingenious and meticulous researchers. Their work has been excellently reviewed by-among o...
| Main Author: | |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1971, 1971
|
| Edition: | 1st ed. 1971 |
| Series: | Monographs on Endocrinology
|
| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- I. Zona Glomerulosa of the Adrenal Cortex: Source of Aldosterone
- II. Pathway of Aldosterone Biosynthesis
- III. Aldosterone Biosynthesis by Cell-Free Systems
- IV. Factors Directly Influencing Aldosterone Biosynthesis in Short-Term Incubation or Perfusion Experiments
- 1. Angiotensin II
- 2. Monovalent Cations
- 3. Bivalent Cations
- 4. ACTH
- 5. Cyclic AMP
- 6. NADPH
- 7. Serotonin
- 8. Specific Inhibitors of Steroidogenic Enzymes
- 9. Inhibitors of Protein Synthesis
- 10. Steroid Hormones
- 11. Ouabain
- V. Alterations in Aldosterone Biosynthesis and Secretion in Long-Term Experiments and Diseases
- 1. Alterations in Sodium Balance
- 2. Alterations in Potassium Balance
- 3. Exogenous Angiotensin and Renin
- 4. Renal Hypertension
- 5. Bilateral Nephrectomy
- 6. Hypophysectomy and Hypopituitarism
- 7. Lesions of the Central Nervous System
- 8. Mineralocorticosteroids
- 9. Glucocorticosteroids and ACTH
- 10. Estrogens and Progestogens
- 11. Heparin and Heparinoids
- VI. Conclusions
- 1. Multiplicity of Aldosterone-Stimulating Substances
- 2. “Adrenoglomerulotropins”
- 3. Uniform Mode of Action of Aldosterone-Stimulating Compounds
- 4. Regulation of the Final Steps of Aldosterone Biosynthesis
- 5. Zona Glomerulosa Width
- 6. Species Differences
- 7. Predominance of the Renin-Angiotensin System in the Physiological Control of Aldosterone Secretion?
- 8. Multifactorial Control of Aldosterone Biosynthesis
- References
- Acknowledgements