Endocytosis From Cell Biology to Health, Disease and Therapy

(Director: Pierre J. COURTOY) Two years after its first gathering in Oeiras, Portugal, the European Endocytosis Group convened for a second workshop at the Pasteur Institute, Paris, on October 1-5, 1990. The meeting is reported in detail in this volume; a preliminary coverage, based on the overviews...

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Bibliographic Details
Other Authors: Courtoy, Pierre J. (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg Springer Berlin Heidelberg 1992, 1992
Edition:1st ed. 1992
Series:Nato ASI Subseries H:, Cell Biology
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • 1.4. Cell-free analysis of endocytic traffic
  • Effect of ATP?S on the formation of coated vesicles in broken HeLa cells
  • ATP is required for receptor-mediated endocytosis both in vivo and in vitro
  • Regulation of endocytic membrane traffic
  • The interaction of late endosomes with lysosomes in a cell-free system
  • Roundtable. Cell-free systems
  • 1.5. Molecular processing by endosomes
  • Regulation of ATP-dependent endosome acidification
  • Degradation of insulin and glucagon in isolated liver endosomes. Functional relationships with ATP-dependent endosomal acidification and partial characterization of degradation products
  • Signaling of receptor tyrosine kinases across the endosomal membrane
  • 1.6. Recycling pathways
  • Membrane recycling in the epithelium of seminal vesicle intersects the secretory pathway
  • Endocyticpathways
  • Intracellular traffic of the growth factor interleukin-2 and its receptors in human T lymphocytes
  • Endocytosis. Molecular mechanism and role in the immune response
  • Endocytosis of CD4 in lymphoid and non-lymphoid cells
  • Role of transepithelial transport in triggering a mucosal immune response and in delivery of mucosal antibodies into secretions
  • 2.2. Phagocytosis and intracellular pathogens
  • Overview on the relations of pathogenic microorganisms with their host cell
  • Intracellular growth of Mycobacterium avium in macrophages. Consequences on membrane traffic and exchange of contents between endosomes, lysosomes and phagosomes
  • Morphology, composition and functions of the endocytic compartment housing Leishmania amazonensis in infected macrophages
  • Entry into eukaryotic cells and intracellular movement of Shigella flexneri
  • 2.3. Entry of viruses and toxins
  • On the role of endocytosis in the entry of animal viruses
  • Endocytic uptake of ricin and shiga toxin
  • Endocytosis of Clostridium spiroforme binary toxin by Hep2 cells
  • 2.4. Lysosomal diseases
  • Plasma membrane biogenesis and vesicle traffic in polarized hepatocytes. What can perturbations tell us ?
  • Plasma membrane polarity of rat hepatocytes in primary culture
  • Sorting of endogenous proteins in intestinal epithelial cells
  • Lipid sorting by the formation of microdomains of sphingolipids. A model and its consequences
  • 1.10. Transcytosis
  • Analytical subcellular fractionation of receptor-mediated transcytosis in rat hepatocytes
  • Temperature dependence of transcytotic pathways in rat liver
  • Fc receptor-mediated endocytosis in polarized and nonpolarized cells
  • Endocytosis in MDCK cells
  • Protein handling from apical and basolateral surfaces in rat and rabbit renal proximal tubules
  • II. Endocytosis in Health, Disease and Therapy
  • 2.1. Endocytosis in the immune response
  • Antigen processing in B lymphocytes
  • Endocytosis and biosynthetic transport of murine MHC class II molecules in antigen-presenting cells
  • Two recycling pathways of epidermal growth factor-receptor complexes in A431 cells
  • Oligosaccharide reprocessing of plasma membrane glycoproteins
  • 1.7. Biogenesis of lysosomes
  • Lysosomal enzyme transport between Golgi and endosomes
  • The nineteen amino acid-cytoplasmic tail of lysosomal acid phosphatase contains an endocytosis signal necessary and sufficient for targeting to lysosomes
  • Biochemical characterization, structure and transport of lysosomal integral membrane proteins
  • Mannose phosphate-independent membrane association of lysosomal enzymes occurs after passage of the Golgi complex
  • 1.8. Heterogeneity of lysosomes and autophagy
  • LGP10D10, a lysosomal membrane protein
  • Receptor-mediated endocytosis in liver endothelial cells. Evidence of lysosomal heterogeneity
  • Autophagic-endocytic interactions in hepatocytes
  • 1.9. The biogenesis of epithelial polarity
  • I. Structure, Dynamics and Functions of the Endocytic Apparatus
  • 1.1. Surface events. Mobility and clustering
  • . Dynamic cytomatrix-membrane interactions investigated with Nanovid microscopy
  • Analysis of receptor dynamics, as studied with surface replicas
  • Surface distribution and pathway of internalization of C3b receptors (CR1) in human neutrophils
  • 1.2. Clathrin-coated pits and clathrin-independent endocytosis
  • The dynamics of clathrin coats in living cells measured by advanced fluorescence microscopy
  • Assembly proteins and adaptors in clathrin-coated vesicles
  • Molecular biology of the adaptins
  • Clathrin-independent endocytosis
  • 1.3. Dynamics of endosomes
  • New insights into the endocytic pathway
  • The compartments of the endocytic pathway
  • Protein exchange within the lysosome and the pre-lysosome compartment. A mechanism for maintaining organelle functionality ?
  • Endosomal pH regulation and the maturation model for lysosome biogenesis
  • Correlation between residual activity of a lysosomal hydrolase and the severity of the resulting storage disease
  • Lysosomes as suicide bags
  • Lysosomal storage disorders and toxicity induced by aminoglycoside antibiotics and polyanionic peptides
  • 2.5. Endocytosis in non-mammalian cells
  • Endocytosis in the emergence of eukaryotic life
  • Endocytosis in plants. Problems and perspectives
  • Receptor-mediated endocytosis of ?-factor by Saccharomyces cerevisiae a cells
  • Receptor-mediated endocytosis in Trypanosoma brucei
  • 2.6. Endocytosis and drug targeting
  • Lysosomes of Leishmania mexicana sp. as targets for potential therapeutic agents
  • Glycosylated polymers as carriers fortargeting antiviral and antiparasite drugs
  • Immunotoxins
  • Directory of participants