The Collagens: Biochemistry and Pathophysiology
Main Author: | |
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Format: | eBook |
Language: | English |
Published: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1992, 1992
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Edition: | 1st ed. 1992 |
Subjects: | |
Online Access: | |
Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- 11.5.2.1 Dupuytren’s Contracture
- 11.5.2.2 Carpal Tunnel Syndrome
- 11.6 Joints
- 11.6.1 Role of Collagen in the Structure and Function
- 11.7 Skeletal Muscle
- 11.7.1 Role of Collagen in the Structure and Function
- 11.7.2 Collagen in the Pathology
- 11.8 Collagen in Rheumatic Disorders
- 11.8.1 Rheumatoid Arthritis
- 11.8.2 Osteoarthrosis
- 11.8.3 Animal Models of Rheumatic Disorders
- 12 Cardiovascular System
- 12.1 Introduction
- 12.2 The Heart
- 12.2.1 General Structural Features
- 12.2.2 Collagen in the Normal Heart Muscle
- 12.2.3 Collagen in Myocardial Hypertrophy
- 12.2.4 Collagen in Myocardial Infarction
- 12.2.5 Collagen in the Valves inHealth and Disease
- 12.3 Vessels
- 12.3.1 General Characteristics
- 12.3.2 Collagen in the Normal Vessel Wall
- 12.3.3 Atherosclerosis
- 12.3.4 Hypertension
- 13 Respiratory System
- 13.1 General Structural Features
- 13.2 Collagen Content in the Lungs
- 13.3 Cells Involved in Collagen Production
- 9.17 Hereditary Disorders of Collagen Metabolism in Animals
- 10 Collagen Diseases
- 10.1 Introduction
- 10.2 Scleroderma and Related Conditions
- 10.3 Other Collagen Diseases
- 10.4 Drug-Induced Lupus-Like Syndrome
- 11 Musculoskeletal System
- 11.1 Introduction
- 11.2 Bone
- 11.2.1 Structure and Function
- 11.2.2 Collagen in Bone
- 11.2.3 Collagen in Pathology of Bone
- 11.2.3.1 Disturbed Regulation of Calcium and Phosphorus Metabolism
- 11.2.3.2 Osteoporosis
- 11.2.3.3 Paget’s Disease
- 11.3 Cartilage
- 11.3.1 Structure and Function
- 11.3.2 Collagens of the Cartilage
- 11.4 Intervertebral Disc
- 11.4.1 Structure and Function
- 11.4.2 Collagen in the Intervertebral Disc
- 11.4.3 Collagen in Pathology of the Intervertebral Disc
- 11.4.3.1 Age-Related Degeneration
- 11.4.3.2 Chemonucleolysis
- 11.4.3.3 Scoliosis
- 11.5 Tendons and Related Structures
- 11.5.1 Structure and Function
- 11.5.2 Collagen in Tendinous Pathology
- 7.5 Insulin and Glucagon
- 7.6 Prolactin
- 7.7 Histamine
- 8 Immunobiology of Collagen
- 8.1 Introduction
- 8.2 Antigenicity of Collagen and Procollagen
- 8.3 Immune Response to Collagens and Procollagens
- 8.4 Effect of Cytokines on Collagen Metabolism
- 9 Hereditary Disorders of Collagen
- 9.1 Introduction
- 9.2 The Ehlers-Danlos Syndrome
- 9.3 The Marfan Syndrome
- 9.4 Osteogenesis Imperfecta
- 9.4.1 Osteogenesis Imperfecta Type I
- 9.4.2 Osteogenesis Imperfecta Type II
- 9.4.3 Osteogenesis Imperfecta Type III
- 9.4.4 Osteogenesis Imperfecta Type IV
- 9.5 Epidermolysis Bullosa
- 9.6 Chondrodysplasias
- 9.7 Congenital Dislocation of the Hip
- 9.8 The Nail-Patella Syndrome
- 9.9 Hereditary Progressive Glomerulopathy (Alport’s Syndrome)
- 9.10 Homocystinuria
- 9.11Alkaptonuria
- 9.12 Aspartylglycosaminuria
- 9.13 Familial Cutaneous Collagenoma
- 9.14 Focal Dermal Hypoplasia
- 9.15 Hyalinosis Cutis et Mucosae
- 9.16 Fibrodysplasia Ossificans Progressiva
- 24.4.3 Heavy Metals
- 24.4.4 Fluoride
- 24.4.5 Cytostatic Drugs
- 24.4.6 Immunomodulants
- 24.4.7 Antibiotics
- 25 Indices of Collagen Metabolism in Clinical Practice
- References
- 1 Introduction: Historical Outline
- 2 Structure, Heterogeneity, and Distribution
- 2.1 Basic Nomenclature
- 2.2 Triple-Chain Helical Structure
- 2.3 Distribution
- 2.4 Classification and General Structural Features of the Collagens
- 2.5 Type I, Type II, Type III Collagens, and Type I-Trimer Collagen
- 2.6 Type IV Collagen
- 2.7 Type V Collagen
- 2.8 Type VI Collagen
- 2.9 Type VII Collagen
- 2.10 Type VIII Collagen
- 2.11 Type IX Collagen
- 2.12 Type X Collagen
- 2.13 Type XI Collagen
- 2.14 Type XII Collagen
- 2.15 Type XIII Collagen
- 2.16 Proteins Containing a Collagenlike Sequence
- 2.16.1 Acetylcholinesterase
- 2.16.2 Mammalian Lectins
- 2.16.2.1 Complement Component C1q
- 2.16.2.2 Conglutinin
- 2.16.2.3 Mannan-Binding Protein
- 2.16.2.4 Lung Surfactant Protein
- 3 Biosynthesis of Collagen
- 3.1 Introduction
- 3.2 Procollagen Genes
- 3.3 Cleavage of the Signal Peptide
- 3.4 Hydroxylation of Proline and Lysine Residues
- 16 The Skin and Wound Healing
- 16.1 Collagen in the Skin
- 16.2 Collagen in Cutaneous Diseases
- 16.3 Collagen in Keloids
- 16.4 Wound Healing
- 17 The Eye and The Ear
- 17.1 The Eye
- 17.1.1 General Structural Features
- 17.1.2 The Cornea and the Sclera
- 17.1.3 The Uvea
- 17.1.4 The Lens
- 17.1.5 The Vitreous Body
- 17.1.6 The Retina
- 17.1.7 Collagen in Ocular Pathology
- 17.2 The Ear
- 18 Urinary and Reproductive Systems
- 18.1 Introduction
- 18.2 The Urinary System
- 18.3 The Ovary
- 18.4 The Uterus and Pregnancy
- 18.5 Placenta
- 19 Collagen in the Nervous System
- 20 Collagen in Hematology
- 20.1 Collagen and Hematostasis
- 20.2 Collagen in the Bone Marrow
- 20.3 Collagen in the Lymph Nodes
- 21 Collagen and Neoplasia
- 21.1 Introduction
- 21.2 Collagen in the Stroma of Neoplasms
- 21.3 Collagenolysis and Tumor Invasion
- 22 Effect of Nutrition
- 22.1 Malnutrition and Overnutrition
- 22.2 Scurvy
- 23 Effect of Ionizing Radiation
- 5.2 Transcriptional and Translational Control of Collagen Synthesis
- 5.3 Regulation of Collagen Synthesis at the Intracellular Posttranslational Level
- 5.4 Intracellular Degradation of Procollagen
- 5.5 Feedback Inhibition of Biosynthesis of Collagen by Aminoterminal Propeptides
- 5.6 Role of the Free Proline Pool in the Regulation of Collagen Synthesis
- 5.7 Turnover of Collagen
- 6 Collagen in Development, Aging, and Phylogeny
- 6.1 Collagen and Development
- 6.2 Collagen and Aging
- 6.3 Phylogenetic Aspects of Collagen
- 6.3.1 Collagen and Animal Phylogeny
- 6.3.2 Plants and Unicellular Organisms
- 6.3.3 Porifera
- 6.3.4 Coelenterata
- 6.3.5 Platyhelmintha
- 6.3.6 Aschelminthes
- 6.3.7 Annelida
- 6.3.8 Arthropoda
- 6.3.9 Mollusca
- 6.3.10 Echinodermata
- 6.3.11 Chordata
- 7 Hormonal Regulation of Collagen Metabolism
- 7.1 Introduction
- 7.2 Thyroxine, Triiodothyronine, and Thyrotropic Hormone
- 7.3 Glucocorticoids
- 7.4 Growth Hormone
- 3.5 Glycosylation of Hydroxylysine Residues
- 3.6 Glycosylation of Asparagine Residues
- 3.7 Chain Association, Disulfide Bonding, and Formation of the Helical Structure
- 3.8 Conversion of Procollagen to Collagen
- 3.9 Formation of the Supramolecular Structures
- 3.10 Cross-Linking of Collagen
- 3.11 Interaction of Collagen with Components of the Extracellular Matrix
- 3.11.1 General Remarks
- 3.11.2 Collagen-Proteoglycan Interactions
- 3.11.3 Structural Glycoproteins
- 3.11.3.1 Fibronectin
- 3.11.3.2 Laminin
- 3.11.3.3 Entactin and Nitogen
- 3.11.3.4 Chondrionectin
- 3.11.3.5 Fibromodulin
- 4 Degradation
- 4.1 Introduction
- 4.2 General Pathways of Collagen Degradation
- 4.3 Depolymerization
- 4.4 Tissue Collagenases
- 4.5 Collagenolytic Cathepsins
- 4.6 Gelatinases and Collagen Peptidase
- 4.7 Collagenolytic Enzymes of Microbial Origin
- 5 Turnover and Regulation of Collagen Metabolism
- 5.1 Introduction
- 13.4 Collagen and Lung Disease
- 13.4.1 Introduction
- 13.4.2 Fibrotic Lung Disorders
- 13.4.3 Destructive Lung Disorders
- 14 The Liver
- 14.1 Introduction
- 14.2 Collagen Content in the Liver
- 14.3 Collagen Synthesizing Cells
- 14.4 Fibrosis as a Response of the Liver Bioecosystem
- 14.5 Collagen Content in the Fibrotic Liver
- 14.6 Metabolism of Collagen in the Liver
- 14.7 Regulation of Collagen Metabolism and Development of Fibrosis
- 14.8 Collagen in Liver Regeneration
- 14.9 Collagen Metabolism in Diseases of the Bile Ducts
- 14.10 Indices of Collagen Metabolism in Hepatic Disorders
- 15 The Teeth and Periodontal Tissues
- 15.1 Structure and Collagen Content in Normal Teeth
- 15.1.1 Dentin
- 15.1.2 Cementum
- 15.1.3 Enamel
- 15.1.4 Dental Pulp
- 15.1.5 Periodontium
- 15.2 The Role of Collagen in Development of Teeth
- 15.3 Collagen and Dental and Periodontal Pathology
- 15.3.1 Periodontal Disease
- 15.3.2 Hydantoin-Induced Gingival Hyperplasia
- 24 Pharmacological Control of Collagen Metabolism
- 24.1 Introduction
- 24.2 Direct Inhibitors of Collagen Synthesis
- 24.2.1 Pharmacological Control of Hydroxylation of Proline and Lysine Residues
- 24.2.1.1 Structural Analogues of Proline
- 24.2.1.2 Cosubstrates and Cofactors of Hydroxylation
- 24.2.1.3 Fibrostatins
- 24.2.2 Pharmacological Control of Collagen Secretion
- 24.2.3 Pharmacological Control of the Conversion of Procollagen to Collagen
- 24.2.4 Pharmacological Control of Extracellular Processing of Collagen
- 24.2.4.1 Lathyrism
- 24.2.4.2 Penicillamine
- 24 2 4 3 Inhibitors of Lysyl Oxidase with Respect to Pyridoxal
- 24.2.5 Antifibroblast Serum
- 24.3 Pharmacological Control of Collagen Degradation
- 24.3.1 Induction of Collagenolysis
- 24.3.2 Inhibitors of Collagenase Secretion
- 24.3.3 Inhibitors of Mammalian Collagenases
- 24.4 Drugs That Indirectly Affect Collagen Metabolism
- 24.4.1 Nonsteroidal Antiinflammatory Drugs
- 24.4.2 Tissue Extracts