The Reeler Mouse as a Model of Brain Development
Only five years ago, nobody in his right mind would have consid ered publishing a book on reeler as a model for brain develop ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventi...
| Main Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1998, 1998
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| Edition: | 1st ed. 1998 |
| Series: | Advances in Anatomy, Embryology and Cell Biology
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| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- 1 Brain Development in Normal and reeler Mice: The Phenotype
- 1.1 Some Introductory Background
- 1.2 The Early Development of the Normal Cerebral Cortex
- 1.3 Early Cortical Histogenesis in reeler Mutant Mice
- 1.4 The reeler Cerebellum
- 1.5 The reeler Inferior Olivary Complex
- 1.6 The Facial Nerve Nucleus and Other Targets
- 1.7 ECM Components and Cortical Development
- 2 Genetics of reeler and Genomics of reelin
- 2.1 Genetics and the Various Alleles of reeler
- 2.2 Mapping of reeler and Cloning of reelin
- 2.3 Genomic Organization of the reelin Gene
- 3 Topography and Cellular Localization of reelin mRNA and Protein Expression During Brain Development
- 3.1 reelin mRNA Expression During Development
- 3.2 Study of Reelin Protein Expression Using Antibodies to Reelin
- 3.3 Some Questions Raised by the Studies of Reelin Expression
- 4 The reeler Mutation and Brain Evolution
- 4.1 The Evolution of Brain Development: A New Theme?
- 4.2 Comparative Data on Cell Migration, Maturation, Synaptogenesis And Neurogenesis
- 4.3 Comparison of Cortical Plate Development in Emys and Lacerta
- 4.4 Reelin and a Model of Cortical Evolution
- 5 A Model of Cortical Development Inspired by reeler: Facts and Hypotheses
- 5.1 Early Hypotheses on the Actions of the reeler Gene on the Developing Brain
- 5.2 Mouse Disabledl and the Scrambler/yotari Mutations
- 5.3 Cyclin-Dependent Protein Kinase 5 and its Activator p35: Definition of a New Step in Mammalian Cortical Development
- 5.4 Reeler-Type Malformations and Human Neuropathology
- References