Ergot Alkaloids and Related Compounds
| Other Authors: | , |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1978, 1978
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| Edition: | 1st ed. 1978 |
| Series: | Handbook of Experimental Pharmacology
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| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- J. Stimulation of Smooth Muscle by Ergot Alkaloids Mediated by Miscellaneous Mechanisms
- K. Biochemical Identification of Specific Binding Sites for Ergot Alkaloids
- L. References
- IV Effects on the Uterus
- A. Introduction
- B. Actions on Uterine Motor Activity
- C. References
- V Actions on the Heart and Circulation
- A. Actions on Systemic Blood Pressure
- B. Hemodynamic Effects
- C. Effects on Regional Hemodynamics
- D. Actions on the Heart
- E. Pharmacologic Basis for the Clinical Use of Ergot Alkaloids
- F. References
- VI Effects on the Central Nervous System
- A. Introduction
- B. Early Evidence of Central Effects
- C. Whole-Animal Studies
- D. Synaptic Transmission: Catecholaminergic Mechanisms
- E. Synaptic Transmission: Serotoninergic Mechanisms
- F. Brain Metabolism
- G. References
- VII ClinicalPharmacology of Ergot Alkaloids in Senile Cerebral Insufficiency
- A. Introduction
- I Introduction to the Pharmacology of Ergot Alkaloids and Related Compounds as a Basis of Their Therapeutic Application
- II Chemical Background
- A. Occurrence, Biosynthesis, and Production
- B. Structure and Synthesis of the Natural Alkaloids
- C. Chemical Modifications in the Lysergic Acid Half of Ergot Alkaloids
- D. Chemical Modification in the Peptide Part of Ergot Alkaloids
- E. Some Analytical Tools for the Determination of Ergot Alkaloids
- F. Subject Index
- G. References
- III Basic Pharmacological Properties
- A. Introduction
- B. Actions of Ergot Alkaloids at 5-HT Receptors
- C. Actions of Ergot Alkaloids at Dopamine Receptors
- D. Actions of Ergot Alkaloids at Adrenoceptors
- E. The Shape of Ergotamine and Dihydroergotamine in Relation to Their Interaction With ?-Adrenoceptors
- F. Actions of Ergot Alkaloids at Acetylcholine Receptors
- G. Actions of Ergot Alkaloids at Histamine Receptors
- H. Interaction of Ergot Alkaloids With Prostaglandins
- B. Terminology, Etiology, and Pathology of the Aging Process of the Brain
- C. Research Techniques Used in Clinical Pharmacologic Studies of Ergot Alkaloids in Senile Cerebral Insufficiency
- D. Results of Clinical Pharmacology Studies With Ergot Alkaloids
- E. Summary
- F. References
- VIII Some Compounds With Hallucinogenic Activity
- A. Introduction
- B. Discovery of LSD
- C. Effects of LSD in Man
- D. Clinical Applications of LSD
- E. LSD Analogues Tested in Man
- F. Cross-Tolerance
- G. References
- IX Influence on the Endocrine System
- A. Animal Data
- B. Human Data
- C. References
- X Metabolic Effects
- A. Introduction
- B. In Vitro Systems
- C. Intact Animals and Men
- D. Various Actions of Ergot Alkaloids
- E. References
- XI Biopharmaceutical Aspects. Analytical Methods, Pharmacokinetics, Metabolism and Bioavailability
- A. Introduction
- B. Assay of Ergot Alkaloids
- C. Pharmacokinetics
- D. Metabolism
- E. References
- XII Toxicologic Considerations
- A. Introduction
- B. Systemic Toxicity
- C. Effects on Reproductive Processes
- D. Potential Genetic Effects
- E. Interactions Leading to Enhanced Toxicity
- F. Summary
- G. References
- Authors Index