Antineoplastic and Immunosuppressive Agents Part I

Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of kn...

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Bibliographic Details
Main Authors: Sartorelli, Alan C., Johns, David G. (Author)
Format: eBook
Language:English
Published: Berlin, Heidelberg Springer Berlin Heidelberg 1974, 1974
Edition:1st ed. 1974
Series:Handbook of Experimental Pharmacology
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • I Table of Contents
  • Section A: General Considerations: Antineoplastic Agents
  • 1 Agents of Choice in Neoplastic Disease
  • 2 Evaluation of Antineoplastic Activity: Requirements of Test Systems
  • 3 Rational Design of Alkylating Agents
  • 4 Rational Design of Folic Acid Antagonists
  • 5 Rational Design of Purine Nucleoside Analogs
  • 6 Rational Design of Pyrimidine Nucleoside Analogs
  • 7 Basic Concepts of Cell Population Kinetics
  • 8 Clinical Applications of Cell Cycle Kinetics
  • 9 Metabolic Events in the Regulation of Cell Reproduction
  • 10 Site of Action of Cytotoxic Agents in the Cell Life Cycle
  • 11 Pharmacokinetic Models for Antineoplastic Agents
  • 12 Absorption, Distribution, and Excretion of Antineoplastic and Immunosuppressive Agents
  • 13 Transport of Antineoplastic Agents
  • 14 Metabolism of Cancer Chemotherapeutic Agents via Pathways Utilized by Endogenous Substrates
  • 15 Metabolism of Cancer Chemotherapeutic Agents via Pathways Utilized by Xenobiotics
  • 16 Theoretical Considerations in the Chemotherapy of Brain Tumors
  • 17 The Constancy of the Product of Concentration and Time
  • 18 Biochemical Aspects of Selective Toxicity
  • 19 Mechanisms of Resistance
  • 20 Combination Chemotherapy: Basic Considerations
  • 21 Combination Chemotherapy: Clinical Considerations
  • 22 Tests Predictive of Cytotoxic Activity
  • 23 Metabolic Changes Induced by Ionizing Radiations
  • 24 Radiation Research: Survival Kinetics
  • 25 Clinical and Laboratory Investigation of Combination Radiation and Chemical Therapy
  • 26 Tumor Immunotherapy
  • Section B: General Considerations: Immunosuppressive Agents
  • 27 Evaluation of Immunosuppressive Agents
  • 28 Immunosuppressive Agents
  • 29 Clinical Utility of Immunosuppressive Agents
  • Author Index