The Selection of Doses in Chronic Toxicity/Carcinogenicity Studies Age-Associated (Geriatric) Pathology: Its Impact on Long-Term Toxicity Studies
The International Life Sciences Institute (ILSI) is a scientific foundation which addresses critical health and safety issues of national and international concern. ILSI promotes international cooperation by providing the mechanism for sci entists from government, industry and universities to work...
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| Format: | eBook |
| Language: | English |
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Berlin, Heidelberg
Springer Berlin Heidelberg
1984, 1984
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| Edition: | 1st ed. 1984 |
| Series: | Current Issues in Toxicology
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| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- The Selection of Doses in Chronic Toxicity/Carcinogenicity Studies
- I. Introduction
- II. Factors Relating to the Dose Selection
- III. Principles for Dose Selection
- IV. Evaluation and Interpretation of Experimental Findings
- V. Recommendations for Future Research on Dose Selection
- VI. Summary
- VII. Glossary of Terms — As They Pertain to Toxicology
- VIII. References
- Age-Associated (Geriatric) Pathology: Its Impact on Long-Term Toxicity Studies
- I. Introduction
- II. Types of Long-Term Tests
- III. Factors Related to the Aging Process that Influence the Design and Conduct of Long-Term Rodent Studies
- IV. Age-Associated Diseases: How They Complicate Long-Term Toxicity Studies
- V. Effect of Aging on Drug Metabolism
- VI. Duration of Long-Term Studies
- VII. Cost of Conducting Toxicity Studies with Durations of 18, 24, or 30 Months
- VIII. Conclusions
- IX. Areas in Need of Future Research
- X. Summary
- XI. References