HMG-CoA Reductase Inhibitors
HMG-CoA reductase inhibitors (statins) are established drugs for the treatment of hypercholesterolemia. Furthermore, they induce regression of vascular atherosclerosis as well as reduction of cardiovascular-related morbidity and death in patients with and without coronary artery disease. This book d...
| Other Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
Basel
Birkhäuser
2002, 2002
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| Edition: | 1st ed. 2002 |
| Series: | Milestones in Drug Therapy
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| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- History and development of HMG-CoA reductase inhibitors
- Structure and mechanisms of action of HMG-CoA reductase inhibitors
- Sterol-regulatory element binding proteins (SREBPs): gene-regulatory target of statin action
- Cellular effects of HMG-CoA reductase inhibitors on blood cells (monocytes, macrophages, platelets)
- Pleiotropic effects of HMG-CoA reductase inhibitors on cells of the vascular wall
- Indications and contra-indications for statin treatment (primary and secondary prevention of hypercholesterolemia)
- Clinical experience: studies with HMG-CoA reductase inhibitors
- Cost-effectiveness of statins in primary and secondary prevention of coronary heart disease