| Summary: | Surveying one of today's most powerful new methodologies, Durum and Muegge assemble in Cytokine Knockouts a unique compendium of the latest information on cytokine knockout mice. Each chapter-written by the leading scientists who created or studied each knockout-illuminates the physiological consequences of deficiency in that cytokine and relates the phenotype to other knockout mice and to human diseases. The effects discussed range from diseases of the bowel, lung, heart, blood, kidney, and liver to immune deficiency, developmental defects, and autoimmunity. Most of the key knockouts of cytokines or receptors, including IL-1 through 8, IFNs, TGFs, TNF, LT, CD40, LIF, CSFs, c-mpl, gp130, and ICE, are thoroughly reviewed. Cytokine Knockouts' many distinguished contributors crystallize their insights into the role of cytokines in health and disease, explain important new concepts in human and animal diseases, and indicate which cytokines should (and should not) become pharmacological targets. Their book offers an authoritative synthesis and review of this important new field and will immediately become a standard resource for today's biomedical researchers
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