MHC Molecules: Expression, Assembly and Function
3 nant expression systems have been used to make MHC molecules con taining a single peptide of interest. To date, fifteen single peptide class I structures (incorporating three different HLA and two different H-2 allotypes/isotypes) and four additional class II structures (two single peptide comple...
| Main Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
New York, NY
Springer US
1996, 1996
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| Edition: | 1st ed. 1996 |
| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- Relating Specificity to the Structure of Polymorphic TAP Molecules
- Length of Transported Peptides
- TAP-Dependent and Independent Presentation
- TAP and Disease
- Concluding Remarks
- 4. Molecular Chaperones in MHC Class I and Class II Biosynthesis and Assembly
- Introduction: ER Resident Molecular Chaperones
- Molecular Chaperones Implicated in Class I Biosynthesis and Assembly
- Molecular Chaperones Implicated in MHC Class II Biosynthesis and Assembly
- Quality Control of MHC Molecules Mediated by Molecular Chaperones
- 5. Polypeptide Release from Lysosomes
- Synthesis and Transport of Lysosomal Hydrolases
- Entry of Degradation Substrates
- Lysosomal Hydrolysis
- Polypeptide Release from Lysosomes
- Possible Immunological Relevance
- Conclusion
- 6. Intracellular Trafficking of MHC Class II Molecules
- Assembly of MHC Class II Molecules in the ER and Early Stages of Transport
- Processing Intermediates of Invariant Chain
- 16. Peptide-Mediated Regulation of Allergic Diseases
- The Role of CD4+ T Cell Subsets
- The Immunological Objectives of Allergy Therapy
- Regulation of Specific T Cells by Peptides
- Deviation of Thl/Th2 Phenotype of the Responder Population
- 17. Genetic Modulation of Antigen Presentation
- Vaccines
- Genetic Immunization for Viral Diseases
- Treatment of Autoimmune Disease
- Conclusion
- Post-Golgi Trafficking of MHC Class II Molecules and Sites of Invariant Chain Degradation
- Intracellular Sites of Assembly of Peptide:MHC Class II Complexes
- 7. The Role of HLA-DM in Class II Antigen Presentation
- DM Sequence and Structure
- Regulation of Expression
- Genomic Organization of DM Genes
- Evolutionary Considerations
- DM Polymorphism
- Analysis of DM Mutant Cells
- The Mechanism of DM Action
- The Biology of Antigen Processing
- The Biosynthesis and Maturation of Class II
- Conclusion
- 8. Crystallographic Analysis of Peptide Binding by Class I and Class II Major Histocompatibility Antigens
- Class I Major Histocompatibility Antigens
- Class II Major Histocompatibility Antigens
- Similarities and Differences Between Class I and Class II Major Histocompatibility Antigens
- 9. HLA and Disease: Molecular Basis
- Tissue Typing Techniques
- Epidemiological Analysis
- Paradigms of Diseases Associated with the MHC
- HLA-B27 and Ankylosing Spondylitis
- Concluding Remarks
- 13. Cooperative Recognition of MHC Class II Molecules:Peptide Complexes by the T Cell Receptor and CD4
- TCR Recognition of MHC Class II:Peptide Complexes
- CD4 Binding to MHC Class II Molecules
- CD4 Interaction With the TCR:CD3 Complex
- Conclusions
- 14. Receptors for MHC Class I Molecules in Human Natural Killer Cells
- MHC Class I Molecules Inhibit NK Cell Cytotoxicity
- Murine NK Inhibitory Receptors
- Human NK Inhibitory Receptors
- A New Family of Immunoglobulin-Superfamily (Ig-SF) Genes Selectively Expressed in Human NK Cells
- Evidence That NK-Specific Ig-SF Genes May Encode Human Receptors for Class I Molecules
- NK Recognition of MHC Class I Molecules Is Mediated by a Complex System
- 15. The MHC in Host-Pathogen Evolution
- Selection Acting on the Human Host
- Pathogen Avoidance of T Cell Recognition
- Mechanisms of Decreasing Antigen Presentation
- Mechanisms of Avoiding T Cell Recognition of Specific Epitopes
- Perspective
- 1. Major Histocompatibility Antigens: An Introduction
- 2. The Major Histocompatibility Complex Genes and Their Transcriptional Regulation
- The Murine Major Histocompatibility Complex
- The Major Histocompatibility Complex of Humans, the HLA
- Developmental and Tissue-Specific Expression of MHC Genes
- Role of Aberrant Expression of MHC Gene Products in Immunologic Disease
- Cis-Elements and Transcription Factors That Control MHC Class I Gene Expression
- Factors and Elements That Control MHC Class II Gene Expression
- Models of Activation and Repression
- Concluding Comments
- 3. TAP Peptide Transporters and Antigen Presentation
- Evidence for Peptide Translocation by TAP
- Tap Genes and Sequences
- TAP as Member of the ABC Transporter Family
- Structure and Assembly of the TAP Complex
- In Vitro Assays for Peptide Binding and Transport by TAP
- Sequence Specificity of Peptide Transport by Different TAP Molecules
- MHC II and Disease
- Concluding Remarks
- 10. Epitope Prediction Algorithms for Class I MHC Molecules
- Elucidation of Peptide-Binding Motifs
- Anchor Residues
- Peptide-Binding Assays
- Physical Basis for Peptide-Binding Motifs
- Prediction of Binding Peptides
- Exceptional Peptides
- Peptide Binding and Antigenicity
- Conclusions
- 11. Options for TCR Interactions: TCR Agonists, Antagonists and Partial Agonists
- Introduction: Smart and Dumb T Cell Receptors
- Full Agonists, Partial Agonists and Antagonists
- What Do TCR Partial Agonists and Antagonists Do?
- T Cell Development
- The Direction of Mature T Cell Responses
- The Two Edged Sword: Antagonists as Protectors and Perpetrators of Disease
- How Do Antagonist/Partial Agonists Work?
- Concluding Remarks
- 12. Role of Ligand Density in T Cell Reactions
- Background
- The Study of Peptides Recognized by CD8+ CTL
- What Determines the Efficacy of CTL-Mediated Target Cell Lysis?
- Role of Ligand Density