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Molecular Radiation Biology The Action of Ionizing Radiation on Elementary Biological Objects

There can hardly be any doubt that radiation will continue to be an im­ portant factor in our lives. Present and future advances in atomic tech­ nology urgently require further work on research and development in the field of radiation biology if the maximum benefit is to be obtained at minimal risk...

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Bibliographic Details
Main Authors: Dertinger, Hermann, Jung, Horst (Author)
Format: eBook
Language:English
Published: New York, NY Springer New York 1970, 1970
Edition:1st ed. 1970
Series:Heidelberg Science Library
Subjects:
Medicine / Research
Life Sciences
Biology / Research
Biomedical Research
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • 11.7. Translation
  • References
  • 12. The Action of Radiation on Viruses
  • 12.1. Basic Properties of Viruses
  • 12.2. Inactivation of Viruses containing Single-Stranded Nucleic Acids
  • 12.3. Inactivation of Viruses containing Double-Stranded DNA
  • 12.4. Repair of Radiation Damage in Viral DNA
  • 12.5. BU Effect
  • References
  • 13. The Action of Radiation on Bacteria
  • 13.1. Some Basic Properties of Bacteria
  • 13.2. Inactivation of Bacteria
  • 13.3. Bacterial DNA as the Critical Target
  • 13.4. Repair of UV Damage
  • 13.5. Repair of Damage caused by Ionizing Radiation
  • 13.6. Genetic Control of Repair in Bacterium E. coli
  • 13.7. Micrococcus Radiodurans
  • References
  • 14. Radiation Sensitivity and BiologicalComplexity
  • 14.1. Attempts at a Systematic Approach
  • 14.2. What is Radiation Sensitivity?
  • References
  • 4.1. X- and Gamma-Radiation
  • 4.2. Neutrons
  • 4.3. Charged Particles
  • 4.4. Uptake of Energy by Molecules
  • 4.5. The Energy Distribution of Secondary Electrons
  • 4.6. Energy Deposited per Primary Interaction
  • References
  • 5. Target Theory and Action Cross Section
  • 5.1. Establishment of a Rigid Concept of a “Hit”
  • 5.2. Target Theory
  • 5.3. Theory of the Action Cross Section
  • 5.4. Relative Biological Effectiveness
  • References
  • 6. Direct and Indirect Action of Radiation
  • 6.1. The Direct Effect
  • 6.2. Indirect Effect in Solutions
  • 6.3. Indirect Effect in Cells
  • 6.4. Indirect Effect in the Dry State
  • 6.5. Protective and Sensitizing Agents
  • References
  • 7. The Temperature Effect
  • 7.1. Experimental Observations
  • 7.2. Temperature Effect and the Indirect Action of Radiation.
  • 7.3. LET-Dependence of the Temperature Effect
  • 7.4. The“Thermal Spike” Model
  • References
  • 8. The Oxygen Effect
  • 8.1. The Oxygen Effect in Macromolecules
  • 1. Introduction
  • 1.1. Historical Survey
  • 1.2. Dose-Response Curves and Special Aspects of Radiation Action
  • 1.3. The Temporal Stages of Radiation Action
  • 1.4. The Significance of Molecular Radiation Biology
  • 1.5. An Introduction to Molecular Radiation Biology
  • References
  • 2. The Hit Theory
  • 2.1. Basic Concepts
  • 2.2. Single and Multiple Hit Phenomena
  • 2.3. Dose-Response Curves of Multiple Target Systems
  • 2.4. The Influence of Biological Variability on the Form of Dose-Response Curves
  • 2.5. The “Relative Steepness” of the Dose-Response Curve
  • 2.6. Possibilities of Deception by Single-Hit Curves
  • References
  • 3. The Stochastics of the Action of Radiation
  • 3.1. Kinetic Interpretation of the Dose-Response Curve
  • 3.2. Multi-Hit Curves
  • 3.3. Reverse Processes
  • 3.4. A Formalistic Description of Dose-Response Curves
  • 3.5. Dose-Response Curves of Colony Formation
  • References
  • 4. Primary Processes of Energy Absorption
  • 8.2. An Oxygen Effect Hypothesis
  • 8.3. The Oxygen Effect in Bacteria
  • 8.4. Oxygen Effect and LET
  • References
  • 9. The Action of Radiation on Enzymes: The Example of Ribonuclease
  • 9.1. Structure and Function of Ribonuclease
  • 9.2. Inactivation Kinetics
  • 9.3. Radiation-Induced Radicals
  • 9.4. Changes in Irradiated Enzyme Molecules
  • 9.5. Separation and Identification of Irradiation Products
  • 9.6. Amino Acid Analysis
  • 9.7. Mechanisms of Inactivation
  • References
  • 10. Physico-Chemical Changes in Irradiated Nucleic Acids
  • 10.1. The Structure of DNA
  • 10.2. Radiation-Induced Radicals
  • 10.3. Chemical Changes in Irradiated DNA
  • 10.4. Breaks in the Polynucleotide Chains
  • 10.5. Intermolecular Cross-Linking
  • 10.6. Rupture of Hydrogen Bonds
  • References
  • 11. Inactivation of Nucleic Acid Functions
  • 11.1. Functions of Nucleic Acids
  • 11.2. Infectivity
  • 11.3. Transformation
  • 11.4. Priming Activity of DNA
  • 11.5. Enzyme Induction
  • 11.6. DNA-mRNA Hybrids

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